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TLK2 Protein, Human, Recombinant (aa 397-772)

产品编号 TMPY-04401

别名: HsHPK, PKU-ALPHA, PKU-α, tousled-like kinase 2

TLK2 Protein, Human, Recombinant (aa 397-772) is expressed in Baculovirus insect cells. The predicted molecular weight is 43.6 kDa and the accession number is Q86UE8-1.

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TLK2 Protein, Human, Recombinant (aa 397-772)

规格	价格/CNY		货期	数量
50 μg	￥ 3,170		5日内发货

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参考文献

生物活性	Kinase activity untested
产品描述	TLK2 Protein, Human, Recombinant (aa 397-772) is expressed in Baculovirus insect cells. The predicted molecular weight is 43.6 kDa and the accession number is Q86UE8-1.

种属	Human
表达系统	Baculovirus Insect Cells
标签	Tag Free
蛋白编号	Q86UE8-1
别名	HsHPK, PKU-ALPHA, PKU-α, tousled-like kinase 2
蛋白构建	The Human TLK2 (Q86UE8-1) (Leu397-Asn772) was fused with two additional amino acids (Gly & Pro) at the N-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	43.6 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Supplied as sterile 20 mM Tris, 500 mM NaCl, 3 mM DTT, 10% glycerol, pH 8.0.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.
研究背景	Serine / threonine-protein kinase tousled-like 2, also known as PKU-alpha, Tousled-like kinase 2 and TLK2, is a nucleus protein which belongs to the protein kinase superfamily and Ser/Thr protein kinase family. The tousled-like kinases are an evolutionarily conserved family of proteins implicated in DNA repair, DNA replication and mitosis in metazoans and plants. Their absence from the yeasts and other eukaryotic 'microbes' suggests a specific role for them in the development of multicellular organisms. Tousled-like kinase 2 / TLK2 is widely expressed. It is present in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle. It is also found in adult cell lines. Tousled-like kinase 2 / TLK2 contains one protein kinase domain. Tousled-like kinase 2 / TLK2 is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.

参考文献

1. Sillje HHW. et al., 2001,Curr Biol. 11: 1068-73. 2. Groth A. et al., 2003, EMBO J. 22: 1676-87. 3. Beausoleil SA. et al., 2004, Proc Natl Acad Sci. 101: 12130-5. 4. Mayya V. et al., 2009, Sci Signal. 2: RA46. 5. Oppermann FS. et al., 2009, Mol Cell Proteomics. 8: 1751-64.

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Keywords

TLK2 Protein, Human, Recombinant (aa 397-772) HsHPK PKU-ALPHA PKU-α tousled-like kinase 2 recombinant recombinant-proteins proteins protein

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