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SEMA3A Protein, Mouse, Recombinant (hFc)

产品编号 TMPY-02360

别名: Semad, Hsema-I, coll-1, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A, SEMA1, SemD

SEMA3A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 87.7 kDa and the accession number is O08665.

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SEMA3A Protein, Mouse, Recombinant (hFc)

规格	价格/CNY		货期	数量
50 μg	￥ 2,530		5日内发货

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生物活性	Testing in progress
产品描述	SEMA3A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 87.7 kDa and the accession number is O08665.

种属	Mouse
表达系统	HEK293 Cells
标签	N-hFc
蛋白编号	O08665
别名	Semad, Hsema-I, coll-1, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A, SEMA1, SemD
蛋白构建	The N-terminal fragment (Lys 26-Phe 546) of Mouse SEMA3A (O08665) was fused with the Fc region of Human IgG1 at the N-terminus.
蛋白纯度	> 80 % as determined by SDS-PAGE
分子量	87.7 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Semaphorins are a family of secreted and cell-bound signaling molecules defined by the presence of a common 5 aa Sema domain. They are best characterized in relation to axon guidance during development of the nervous system. The functions of Semaphorins 3A (SEMA3A) are mediated primarily through binding to the Neuropilin-1 (Npn-1) and Plexin-A1 coreceptor complex. Neuropilins lack a signaling-competent cytoplasetmic domain and ensure semaphorin binding, whereas the transmembrane receptor plexin mediates the intracellular response. As the first identified vertebrate semaphorin, SEMA3A functions either as a chemorepulsive agent inhibiting axonal outgrowth, or as a chemoattractive agent stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Its overexpression is associated with schizophrenia which is seen in various human tumor cell lines, and aberrant release is associated with the progression of Alzheimer's disease

参考文献

1. Giordano,A. et al., 2003, J Neurocytol.32(4):345-352. 2. Good, P. F. et al., 2005, J. Neurochem.91(3): 716-736. 3. Gu, C. et al., 2005, Science.307(5707): 265–268. 4. Chadborn,N.H. et al., 2006, J Cell Sci.119(Pt 5):951-957. 5. Schmidt,E.F. et al., 2007, Adv Exp Med Biol.600:1-11.

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Keywords

SEMA3A Protein, Mouse, Recombinant (hFc) SEMA-1 Semad Hsema-I coll-1 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A SEMA 1 SEMA1 SemD recombinant recombinant-proteins proteins protein

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