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S100A1 Protein, Human, Recombinant

产品编号 TMPY-00997

别名: S100-α, S100A, S100 calcium binding protein A1, S100, S100-alpha

S100A1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 10.5 kDa and the accession number is A0A0S2Z4H2.

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S100A1 Protein, Human, Recombinant

规格	价格/CNY		货期	数量
100 μg	￥ 4,460		5日内发货

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生物活性

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参考文献

生物活性	1. Measured by its binding ability in a functional ELISA. 2. Immobilized recombinant human Fc-S100B at 10 μg/mL (100 μl/well) can bind biotinylated human S100A1 with a linear range of 15.6-250 ng/mL. 3. Measured by its ability to bind human His-S100B in functional ELISA.
产品描述	S100A1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 10.5 kDa and the accession number is A0A0S2Z4H2.

种属	Human
表达系统	E. coli
标签	Tag Free
蛋白编号	A0A0S2Z4H2
别名	S100-α, S100A, S100 calcium binding protein A1, S100, S100-alpha
蛋白构建	Human S100A1 (NP_006262.1) (Met 1-Ser 94)
蛋白纯度	> 97 % as determined by SDS-PAGE
分子量	10.5 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	S100A1 is a Ca2+binding protein of the EF-hand type that belongs to the S100 protein family. S100 proteins consisting of at least 19 members exist as dimers in the cytoplasm and/or nucleus of a wide range of cells, and are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation. This protein has been shown to function in the processes including stimulation of Ca2+-induced Ca2+release, inhibition of microtubule assembly, and inhibition of PKC-mediated phosphorylation. Phosphoglucomutase is a target protein whose activity is antagonistically regulated by S100A1, and recently, S100A1 is also identified as a potent molecular chaperone and a new member of the Hsp70/Hsp90 multichaperone complex. S100A1 displays a tissue-specific expression pattern with highest levels in myocardium and is considered to be an important regulator of cardiac contractility. Accordingly, reduced expression or mutations of S100A1 gene have been implicated in cardiomyopathies.

参考文献

1. Remppis, A .et al., 1996, Biochim. Biophs. Acta. 1313: 253-257. 2. Most, P. et al., 2001, Proc. Natl. Acad. Sci. U.S.A. 98: 13889-13894 3. Okada, M. et al., 2004, J. Biol. Chem. 279: 4221-4233. 4. Schafer, W.E. et al., 1995, Genomics. 25: 638-643. 5. Landar, A. et al., 1996, Cell. Calcium. 20: 279-285.

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Keywords

S100A1 Protein, Human, Recombinant S100-α S100A S100 calcium binding protein A1 S100 S-100 S 100 S100-alpha recombinant recombinant-proteins proteins protein

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