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GHR/Growth Hormone R Protein, Human, Recombinant (hFc)

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产品编号 TMPY-07147

GHR/Growth Hormone R Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is P10912.

GHR/Growth Hormone R Protein, Human, Recombinant (hFc)

一键复制产品信息

产品编号 TMPY-07147

GHR/Growth Hormone R Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is P10912.

规格	价格	库存
5 μg	¥ 428	6-8日内发货
10 μg	¥ 683	6-8日内发货
20 μg	¥ 1,130	5日内发货
50 μg	¥ 2,270	5日内发货
100 μg	¥ 4,430	5日内发货
200 μg	¥ 6,480	5日内发货
500 μg	¥ 12,800	5日内发货
1 mg	¥ 25,500	5日内发货

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产品信息

生物活性	Immobilized Growth Hormone Protein, Human, Recombinant (Cat#TMPY-00394) at 2 μg/mL (100 μL/well) can bind GHR/Growth Hormone R Protein, Human, Recombinant (hFc) (Cat#TMPY-07147), the EC50 is 8-26 ng/mL.
产品描述	GHR/Growth Hormone R Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is P10912.
种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	P10912
别名	GHIP,GHBP
蛋白构建	A DNA sequence encoding the Human GHR (P10912) (Ala27-Tyr264) was expressed with the Fc region of human IgG1 at the C-terminus.
蛋白纯度	≥ 90% as determined by SDS-PAGE. ≥ 90% as determined by SEC-HPLC. ≥ 90% as determined by SEC-MALS. (Routinely tested)
分子量	54.39 kDa (predicted); 68.3 kDa (reducing contition, due to glycosylation); 130.5 kDa (SEC-MALS)
内毒素	< 1.0 EU per μg of the protein as determined by the LAL method
缓冲液	Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
复溶方法	Please refer to the lot-specific COA.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Growth hormone receptor, also known as GH receptor and GHR, is a single-pass type I membrane protein which belongs to thetype I cytokine receptor family and type 1 subfamily. GHR contains onefibronectin type-III domain. Growth hormone receptor / GHR is expressed in various tissues with high expression in liver and skeletal muscle. Isoform4of GHR is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform1 expression of GHR in placenta is predominant in chorion and decidua. Isoform4is highly expressed in placental villi. Isoform2of GHR is expressed in lung, stomach and muscle. Growth hormone receptor / GHR is a receptor for pituitary gland growth hormone. It is involved in regulating postnatal body growth. On ligand binding, it couples to the JAK2 / STAT5 pathway. Isoform2of GHR up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. Defects in GHR are a cause of Laron syndrome (LARS) which is a severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may also be a cause of idiopathic short stature autosomal (ISSA) which is defined by a subnormal rate of growth.