The product of CAMK2D gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns. CAMK2D (Calcium/Calmodulin Dependent Protein Kinase II Delta) is located on human chromosome 4q26. 180 organisms have orthologs with human gene CAMK2D.

>75% as determined by SDS-PAGE.