Thiohexam

Name: Thiohexam
Brand: TargetMol
SKU: T9037
Price: 117 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T9037Cas号 95-33-0 一键复制产品信息纯度: 97.33%

很棒

Thiohexam 是一种橡胶硫化促进剂。

Thiohexam

一键复制产品信息

很棒

纯度: 97.33%

货号 T9037Cas号 95-33-0

Thiohexam 是一种橡胶硫化促进剂。

规格	价格	库存
200 mg	¥ 132	现货
500 mg	¥ 213	现货
1 g	¥ 297	现货
5 g	¥ 745	现货
10 g	¥ 1,080	现货
1 mL x 10 mM (in DMSO)	¥ 117	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 97.33%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS 产品操作手册

产品介绍

Thiohexam AI Summary

Thiohexam exhibits a wide range of bioactivities, particularly as an inhibitor in various biochemical and cellular assays. It is a potent inhibitor of ALDH1A1 with an IC50 of 794.3 nM, G9a histone lysine methyltransferase at 1778.3 nM, ROR gamma transcriptional activity at 8912.5 nM, and the vitamin D receptor (VDR) with a potency of 10000.0 nM. Additionally, it inhibits TDP1 in vitro with an IC50 of 39810.7 nM and in cells in the absence of CPT with an IC50 of 16788.9 nM, among other targets. The compound demonstrates cytotoxic activity against SH-SY5Y, HepG2, and MCF7 cells with IC50 values greater than 120000.0 nM, 55000.0 nM, and 89200.0 nM, respectively, indicating varying degrees of cell viability inhibition. Furthermore, Thiohexam has shown significant antiviral activity by reducing SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 26.21% at 10 µM, and in VERO-6 cells with an inhibition rate of 0.03% at the same concentration. Notably, Thiohexam is a strong inhibitor of the SARS-CoV-2 3CL-Pro protease with an IC50 of 770.0 nM and demonstrates 24.67% inhibition at 20 µM, although it is much less effective against the MERS 3CL-Pro protease, with no observed inhibition at 10 µM and an IC50 greater than 10000.0 nM. Additionally, the compound shows mixed results in HDAC6 enzyme inhibition assays: 80.03% inhibition in an enzymatic assay with a commercial peptide substrate, -3.25% inhibition with a custom peptide substrate, and 23.24% inhibition in a hit confirmation assay using a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Thiohexam is a rubber vulcanization accelerator

化学信息

分子量	264.41
分子式	C₁₃H₁₆N₂S₂
CAS No.	95-33-0
Smiles	C1CCC(CC1)NSc1nc2ccccc2s1
密度	1.31~1.34g/cm3

储存&溶解度

存储

溶解度信息

DMSO: 22.5 mg/mL (85.1 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7820 mL	18.9100 mL	37.8201 mL	189.1003 mL
5 mM	0.7564 mL	3.7820 mL	7.5640 mL	37.8201 mL
10 mM	0.3782 mL	1.8910 mL	3.7820 mL	18.9100 mL
20 mM	0.1891 mL	0.9455 mL	1.8910 mL	9.4550 mL
50 mM	0.0756 mL	0.3782 mL	0.7564 mL	3.7820 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。