In cell adhesion assays in which Jurkat cells bound to CS1-conjugated BSA, THI0019 shows a dose-dependent enhancement in cell binding with an EC 50 of 1.7 μM. When VCAM-1 is used as the ligand, THI0019 induces an even more pronounced 100-fold increase in Jurkat cell binding, with an EC 50 of 1.2 μM. THI0019 induces a dose-dependent increase in EPC binding to VCAM-1 (EC 50 of 3.7 μM). THI0019 facilitates the rolling and spreading of cells on VCAM-1 and the migration of cells toward SDF-1α[1].