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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Quorum Sensing-IN-3

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纯度: 99.58%

货号 T78823Cas号 5005-14-1

别名 QS-IN-1

Quorum Sensing-IN-3 (QS-IN-1)是一种对细菌群体感应有抑制作用的化合物，可抑制细菌之间的信息交流，抑制生物膜的形成。

Quorum Sensing-IN-3

Quorum Sensing-IN-3

一键复制产品信息
Rating icon 很棒

纯度: 99.58%

货号 T78823 别名 QS-IN-1Cas号 5005-14-1

Quorum Sensing-IN-3 (QS-IN-1)是一种对细菌群体感应有抑制作用的化合物，可抑制细菌之间的信息交流，抑制生物膜的形成。

规格价格库存数量
1 mg
¥ 1,630
现货
5 mg
¥ 4,900
现货
10 mg
¥ 5,980
现货
25 mg
¥ 7,860
现货
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纯度: 99.58%
颜色: 黄色
性状: Solid
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资源下载:
COA HNMR LCMS产品操作手册

产品介绍

Quorum Sensing-IN-3 AI Summary
Quorum Sensing-IN-3 demonstrates a broad range of bioactivities across various biological processes. It has shown potency in modulating miRNAs and activating promoters such as Rab9, SMN2, and NPC1. It also exhibits inhibitory effects on certain transcriptional activities, including ROR gamma and Menin-MLL interaction, and disrupts DNA repair and genotoxicity. Furthermore, Quorum Sensing-IN-3 has potential antiviral properties, inhibiting viral entry for Lassa Virus, Marburg Virus, and Hepatitis C Virus, as well as interacting with HIV-1 protein Vpr. In cytotoxicity assays, Quorum Sensing-IN-3 shows an LD50 of greater than 30.0 umol/L against human THP1 cells. It demonstrates antimycobacterial activity with an IC90 of 533,000 nM against Mycobacterium kansasii CIT11/06, and variable antibacterial activity against Staphylococcus epidermidis and methicillin-resistant Staphylococcus aureus, with different IC80 values depending on the duration of exposure. Quorum Sensing-IN-3 also has been tested for antifungal activity against several strains, including Trichophyton mentagrophytes, Trichosporon asahii, Candida krusei, and Candida albicans, showing differing degrees of effectiveness and IC values across various time points. Moreover, Quorum Sensing-IN-3 exhibits intrinsic clearance rates in liver cells, with a clearance rate of 64.57 uL/min/(10^6cells)^-1 in rat hepatocytes, 77.62 uL/min/(10^6cells)^-1 in human hepatocytes, and greater than 150.0 mL/min.g^-1 in human liver microsomes. This suggests potential bioactivity related to hepatic clearance processes. Overall, these findings highlight the compound's diverse pharmacological profile..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Quorum Sensing-IN-3 (QS-IN-1) is a compound with inhibitory effects on bacterial community sensing, which inhibits the exchange of information between bacteria and inhibits biofilm formation.
别名QS-IN-1
化学信息
分子量254.31
分子式C14H10N2OS
CAS No.5005-14-1
SmilesO=C(NC1=NC=2C=CC=CC2S1)C=3C=CC=CC3
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

Bacterial
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