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Proquazone

Name: Proquazone
Brand: TargetMol
SKU: T28454
Price: 1260 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 普罗喹宗, Proquazonum, Proquazona, Biarison, Arthrex

货号 T28454Cas号 22760-18-5 一键复制产品信息纯度: 98.23%

很棒

Proquazone (Arthrex) 是一种非甾体抗炎药。

Proquazone

一键复制产品信息

很棒

纯度: 98.23%

货号 T28454Cas号 22760-18-5

别名 普罗喹宗, Proquazonum, Proquazona, Biarison, Arthrex

Proquazone (Arthrex) 是一种非甾体抗炎药。

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
1 mg	¥ 1,260	现货
5 mg	¥ 2,590	现货
10 mg	¥ 3,370	现货
25 mg	¥ 5,480	现货
50 mg	¥ 7,690	现货
100 mg	¥ 9,870	现货
500 mg	¥ 19,800	现货
1 mL x 10 mM (in DMSO)	¥ 1,990	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.23%

颜色: 黄色

性状: Solid

资源下载: COA LCMS HNMR 产品操作手册

产品介绍

Proquazone AI Summary

Proquazone demonstrates a multifaceted pharmacological profile with notable activities in anti-inflammatory, analgesic, antiviral, and enzyme inhibition domains. It exhibits relative oral anti-inflammatory activity in the Evans Blue-Carrageenan pleural assay with a potency of 0.4 compared to indomethacin and shows significant inhibition of PG synthetase (IC50 = 70.0 nM) from bovine seminal vesicles. This compound effectively reduces carrageenan-induced edema in rats, has an ED30 of 10.0 mg/kg for anti-inflammatory action and 20.0 mg/kg for analgesic action when administered orally. However, it causes ulcers in mice at 30 mg/kg but shows no toxicity up to 500 mg/kg. Proquazone also shows inhibition of edema and is effective in inhibiting adjuvant-induced polyarthritis in rats. In antiviral assessments, Proquazone inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM, although the inhibition percentages are relatively low (-4.92% and -0.02%, respectively). It also shows 9.765% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM. The compound demonstrates moderate liver toxicity and potential as a COX-2 selective inhibitor with a Selectivity Index of 400 over COX-1. It also displays human HDAC6 inhibitory activities with enzymatic inhibition percentages of -10.31% and -6.06% with commercial and custom peptide substrates, respectively, and exhibits strong inhibition of EGFR with an IC50 of 2.0 nM. Despite binding to multiple receptors, Proquazone’s substantial activities are primarily inhibitory, with notable binding affinities against PTGS2, Ptgs1, and PDE4D enzymes..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Proquazone (Arthrex) is a nonsteroidal anti-inflammatory agent.
别名	普罗喹宗, Proquazonum, Proquazona, Biarison, Arthrex

化学信息

分子量	278.35
分子式	C₁₈H₁₈N₂O
CAS No.	22760-18-5
Smiles	CC(C)n1c2cc(C)ccc2c(nc1=O)-c1ccccc1
密度	1.12g/cm3

储存&溶解度

存储

溶解度信息

DMSO: 65 mg/mL (233.52 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5926 mL	17.9630 mL	35.9260 mL	179.6300 mL
5 mM	0.7185 mL	3.5926 mL	7.1852 mL	35.9260 mL
10 mM	0.3593 mL	1.7963 mL	3.5926 mL	17.9630 mL
20 mM	0.1796 mL	0.8981 mL	1.7963 mL	8.9815 mL
50 mM	0.0719 mL	0.3593 mL	0.7185 mL	3.5926 mL
100 mM	0.0359 mL	0.1796 mL	0.3593 mL	1.7963 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。