Name: Mezerein
Brand: TargetMol
SKU: T40432
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

待询

生物活性

产品描述	Mezerein is a chemical compound with antileukemic properties and acts as a PKC activator. It effectively inhibits the growth of yeast expressing PKC alpha (IC 50 = 1190 nM), PKC beta1 (IC 50 = 908 nM), and PKC delta (IC 50 = 141 nM). However, it does not inhibit the growth of yeast expressing PKC.
体外活性	Mezerein is an antileukemic principle isolated from Daphne mezereum L[2]. Mezerein (50 ng/mL; 72 hours) potently inhibit tumorigenic murine macrophage cell line M5076 cellular proliferation[3]. Cell Proliferation Assay[3]Cell Line: M5076 cells Concentration: 50 ng/mL Incubation Time: 72 hours Result: Inhibited cellular proliferation (by greater than 90%).
体内活性	Mezerein exhibits antileukemic activity against the P-388 lymphocytic leukemia in mice. Mezerein (50 μg/kg) shows significant inhibitory activity against the P-388 and L-1210 leukemias in mice[2].
别名	欧瑞香脂, 密执毒素

化学信息

分子量	654.70
分子式	C₃₈H₃₈O₁₀
CAS No.	34807-41-5
Smiles	[H][C@@]12O[C@]1(CO)[C@@H](O)[C@]1(O)C(=O)C(C)=C[C@@]1([H])[C@]13O[C@@]4(O[C@]([H])([C@]21[H])[C@@](O4)([C@H](OC(=O)\C=C\C=C\c1ccccc1)[C@H]3C)C(C)=C)c1ccccc1
密度	1.1724 g/cm3 (Estimated)