dtagv-1 hydrochloride

dTAGV-1 hydrochloride 是一种基于 VHL E3 连接酶招募机制的 PROTAC 异双功能降解剂，能高效且选择性地诱导 FKBP12F36V 标签蛋白的体内外降解，同时对野生型 FKBP12 蛋白无影响。

(R,S,S)-VH032-Me TFA 是一种作为 E3 连接酶配体的化合物，可用于合成 dTAGV-1 hydrochloride。

(R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid TFA 是一种由 E3 泛素连接酶配体与连接子构成的共轭物，适用于合成dTAGV-1 hydrochloride。

Degrader targeting mutant FKBP12F36V fusion proteins. Comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a von Hippel-Lindau (VHL)-binding ligand. Induces potent and selective degradation of FKBP12F36V fusion proteins in vitro and in vivo. Selectively degrades FKBP12F36V-EWS/FLI fusion proteins and inhibits cell proliferation in FKBP12F36V-EWS/FLI-expressing Ewing sarcoma cells. Hydrochloride salt (Cat.No. 7374) available; suitable for in vivo use. Negative control dTAGV-1-NEG (Cat. No. 6915) also available. FKBP12F36V can be expressed as a fusion with a target protein of interest using genome engineering techniques, via transgene expression or CRISPR-mediated locus-specific knock-in. Custom knock-in cell lines for the dTAG and aTAG platforms are available from our sister brand R&D Systems. Email TPD@bio-techne.com to enquire. Plasmid vectors for the lentiviral expression and CRISPR-mediated knock-in of FKBP12F36V are available from Addgene.