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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Atrazine

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Rating icon 很棒

纯度: 99.68%

货号 T5626Cas号 1912-24-9

别名 莠去津, Oleogesaprim, Gesaprim, Chromozin, Aktikon

Atrazine (Oleogesaprim) 能够抑制光磷酸化，但通不会在短期内导致致命性或永久性细胞损伤，常用于控制一年生阔叶杂草。

Atrazine

Atrazine

一键复制产品信息
Rating icon 很棒

纯度: 99.68%

货号 T5626 别名 莠去津, Oleogesaprim, Gesaprim, Chromozin, AktikonCas号 1912-24-9

Atrazine (Oleogesaprim) 能够抑制光磷酸化，但通不会在短期内导致致命性或永久性细胞损伤，常用于控制一年生阔叶杂草。

规格价格库存数量
100 mg
¥ 115
现货
500 mg
¥ 248
现货
1 g
¥ 358
现货
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纯度: 99.68%
颜色: 白色
性状: Solid
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产品介绍

Atrazine AI Summary
Atrazine exhibits a diverse range of bioactivities and physicochemical properties. It has a high aqueous solubility with a logarithmic solubility value of -3.55 and a log D value of 2.61, indicating its hydrophobic nature. The compound demonstrates low dissociation constant with a pKa value below 2.0 and shows high permeability through artificial membranes, with a log Pe of -4.21 cm/s in a 70% silicon-30% IPM membrane and a low log Kp of -5.56 cm/s indicating low permeability in human skin. It also has an IC50 of 930.0 nM in inhibiting photosystem II in spinach thylakoids, showcasing potent herbicidal activity against various plant species such as Stellaria media, Lolium perenne, Amaranthus retroflexus, and others, with 100% efficacy against Chenopodium album and Stellaria media at certain dosages. In various bioassays, Atrazine shows the ability to inhibit photosynthetic electron transport in Spinacia oleracea and other plants, with IC50 values indicating significant potency. Additionally, it demonstrates herbicidal properties by affecting the growth of different weed species both pre- and post-emergence. It also inhibits multiple biochemical and physiological pathways in plants such as Lolium multiflorum and Triticum aestivum, influencing photosynthesis, antioxidative enzyme activities, and overall plant growth. Beyond its herbicidal properties, Atrazine shows inhibitory effects on sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells, indicating potential in pharmaceutical applications related to these transporters. Additionally, it exhibits antiviral activity against SARS-CoV-2 by inhibiting its induced cytotoxicity in VERO-6 cells and inhibiting SARS-CoV-2 3CL-Pro protease, albeit with moderate efficacy. Overall, Atrazine's profile includes high permeability through artificial membranes, potent herbicidal activity, effects on plant biochemical pathways, and potential pharmaceutical uses, particularly in viral inhibition and transporter interactions..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Atrazine (Oleogesaprim) is an herbicide that does not occur naturally,and is a selective triazine herbicide. Atrazine (Oleogesaprim) is also a potent endocrine disruptor.
别名莠去津, Oleogesaprim, Gesaprim, Chromozin, Aktikon
化学信息
分子量215.68
分子式C8H14ClN5
CAS No.1912-24-9
SmilesCCNc1nc(Cl)nc(NC(C)C)n1
密度1.23. Temperature:20 °C.
储存&溶解度
存储In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 83.33 mg/mL (386.36 mM), Sonication is recommended.
体内实验配方
10% DMSO+90% Corn Oil: 2.5 mg/mL (11.59 mM), Sonication is recommended.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM4.6365 mL23.1825 mL46.3650 mL231.8249 mL
5 mM0.9273 mL4.6365 mL9.2730 mL46.3650 mL
10 mM0.4636 mL2.3182 mL4.6365 mL23.1825 mL
20 mM0.2318 mL1.1591 mL2.3182 mL11.5912 mL
50 mM0.0927 mL0.4636 mL0.9273 mL4.6365 mL
100 mM0.0464 mL0.2318 mL0.4636 mL2.3182 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

Atrazine
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