Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AR-R17779 hydrochloride 是一种有效和选择性的 nAChR 完全激动剂,对α7和α4β2亚型的Ki 直分别为 92 和 16000 nM。AR-R17779 hydrochloride 可以改善大鼠的学习和记忆能力。AR-R17779 hydrochloride 也具有抗焦虑活性。AR-R17779 hydrochloride 可通过激活抗炎胆碱能(迷走神经)通路减轻炎症。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | AR-R17779 hydrochloride is a potent, selective full agonist of the nAChR, demonstrating K i values of 92 nM for the α7 subtype and 16,000 nM for the α4β2 subtype. It is noted for its ability to enhance learning and memory in rats, suggesting potential therapeutic applications. Additionally, this compound exhibits anxiolytic properties and can mitigate inflammation by activating anti-inflammatory cholinergic (vagal) pathways [1] [2] [4]. |
体外活性 | AR-R17779 is 5-fold more potent and 35000-fold more selective than (-)-nicotine at the α7 nicotinic receptor [1]. AR-R17779 (200 nM; 24 h) inhibits the LPS-induced TNF production in macrophages [4]. |
体内活性 | AR-R17779 (1-5 mg/kg; i.p. twice a day for 7 d) improves arthritis, reduces synovial inflammation, delays onset of disease and protects against joint destruction [3]. AR-R17779 (1-10 mg/kg; s.c. for 3 weeks) improves learning in two radial-arm maze tasks and reverses working memory impairment caused by fimbria-fornix sections in rats [2]. Animal Model: Male DBA/1 mice (8-10 weeks) were subjected to unilateral cervical vagotomy or sham surgery, after which arthritis was induced with type II collagen [3] Dosage: 1, 2.5, 5 mg/kg Administration: I.p. twice daily from day 20 until day 26 Result: Ameliorated arthritis and delayed onset of disease. Reduced erosive disease, cartilage degradation and synovial inflammation. Reduced TNFα levels in plasma and synovial tissue. |
分子量 | 218.68 |
分子式 | C9H15ClN2O2 |
CAS No. | 178419-42-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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