Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Antiparasitic agent-9 (compound 47) is a highly active and orally administered antiparasitic agent, exhibiting potent antiparasitic efficacy against the human parasite [1].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | Antiparasitic agent-9 (compound 47) is a highly active and orally administered antiparasitic agent, exhibiting potent antiparasitic efficacy against the human parasite [1]. |
体内活性 | Antiparasitic agent-9 (compound 47) (15 mg/kg, Orally, twice each day for 7 days) reduces adult worm burden in the jird L. sigmodontis infection model [1]. Antiparasitic agent-9 (2 mg/kg (IV), 10 and 30 mg/kg (PO); once) shows a brain to plasma ratio of 0.08, suggesting limited brain exposure [1]. Animal Model: Female BALB/c mice (infected with L. sigmodontis, 6-8 weeks) [1] Dosage: 15 mg/kg Administration: Orally, twice each day for 7 days Result: Showed a significant worm burden reduction of 59% at 15 mg/kg. Animal Model: Male CD-1 mouse (n = 4) [1] Dosage: 2 mg/kg (IV), 10 and 30 mg/kg (PO) Administration: IV, PO, once (Pharmacokinetic Analysis) Result: Pharmacokinetic Parameters of Antiparasitic agent-9 in male Male CD-1 mouse [1]. PO (30 mg/kg) PO (10 mg/kg) IV (2 mg/kg) C max (μM) 13.9 5.27 ± 0.83 T max (h) 0.50 4.0 ± 2.8 AUC 0-inf (μM·h) 121 68.1±NC CL (mL/min/kg) 3.6 ± 0.22 Vd ss (mL/kg) 0.74 ± 0.08 F (%) 57 brain/plasma [b]/[p] 0.08 efflux ratio (ER) 12 |
分子量 | 384.46 |
分子式 | C18H20N6O2S |
CAS No. | 2516237-50-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Antiparasitic agent-9 2516237-50-4 Inhibitor inhibitor inhibit