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Anti-VE-Cadherin Antibody (1J689)
还可以产品编号 TMAY-00826
Anti-VE-Cadherin Antibody (1J689) 是一种 Rabbit 抗体，靶向 VE-Cadherin。Anti-VE-Cadherin Antibody (1J689) 可用于 ELISA,ELISA(Det),FCM,ICC/IF。
Anti-VE-Cadherin Antibody (1J689)
Anti-VE-Cadherin Antibody (1J689)
还可以产品编号 TMAY-00826
Anti-VE-Cadherin Antibody (1J689) 是一种 Rabbit 抗体，靶向 VE-Cadherin。Anti-VE-Cadherin Antibody (1J689) 可用于 ELISA,ELISA(Det),FCM,ICC/IF。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-VE-Cadherin Antibody (1J689) is a Rabbit antibody targeting VE-Cadherin. Anti-VE-Cadherin Antibody (1J689) can be used in ELISA,ELISA(Det),FCM,ICC/IF. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 1J689 |
| 交叉反应 | Human |
| 验证活性 | 1. Flow cytometric analysis of Human CD144 expression on HUVEC cells. Cells were stained with purified anti-Human CD144, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. 2. Immunofluorescence staining of CDH5 in HUVEC cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-human CDH5 monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). |
| 应用 | ELISA,ELISA(Det),FCM,ICC/IF |
| 推荐剂量 | ELISA: 1:5000-1:10000; ICC-IF: 1:20-1:100; FCM: 1:25-1:100; ELISA(Det): 1:1000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human VE-Cadherin / CD144 / CDH5 (CAA56306.1; Met1-Gln593). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/FITC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human VE-Cadherin / CD144 / CDH5 Protein |
| 抗原种属 | Human |
| 研究领域 | Hemangioblast Markers, Cardiac Stem Cell Markers |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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