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Anti-uPAR/PLAUR Antibody-APC (6L393)
还可以产品编号 TMAY-01335A
Anti-uPAR/PLAUR Antibody-APC (6L393) 是一种 APC-conjugated Mouse 抗体，靶向 uPAR/PLAUR。Anti-uPAR/PLAUR Antibody-APC (6L393) 可用于 FCM。
Anti-uPAR/PLAUR Antibody-APC (6L393)
Anti-uPAR/PLAUR Antibody-APC (6L393)
还可以产品编号 TMAY-01335A
Anti-uPAR/PLAUR Antibody-APC (6L393) 是一种 APC-conjugated Mouse 抗体，靶向 uPAR/PLAUR。Anti-uPAR/PLAUR Antibody-APC (6L393) 可用于 FCM。
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抗原信息
| 产品描述 | Anti-uPAR/PLAUR Antibody-APC (6L393) is a APC-conjugated Mouse antibody targeting uPAR/PLAUR. Anti-uPAR/PLAUR Antibody-APC (6L393) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 6L393 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of human UPAR(CD87) expression on human whole blood granulocytes. Human whole blood granulocytes were stained with APC-conjugated anti-Human UPAR(CD87). The histogram were derived from gated events with the forward and side light-scatter characteristics of viable granulocytes. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This product is a recombinant monoclonal antibody expressed from HEK293 cells. Then conjugated with APC under optimum conditions, the unreacted APC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | Urokinase plasminogen activator (uPA) and/or its receptor (uPAR) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumours. uPAR and uPA levels in both resected tumor tissue and plasma are of independent prognostic significance for patient survival in several types of human cancer. This system has classically been thought to drive tumor progression by mediating directed extracellular proteolysis on the surface of migrating or invading cells, and intervening with this proteolysis by targeting uPAR has been proposed to represent a novel approach for inhibiting tumor progression. uPAR, also known as PLAUR or CD87, has been implicated in the growth, metastasis, and angiogenesis of several solid and hemotologic malignancies. uPAR is a highly glycosylated, 55-60kDa integral membrane protein linked to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. It is part of a cell surface system that also consists of the serine protease uPA and several specific inhibitors (plasminogen activator inhibitors 1 and 2). Additionally, the analysis of CD87 (urokinase-type plasminogen activator receptor - uPAR) expression has a potential role in the diagnostic or prognostic work-up of several hematological malignancies, particularly acute leukemia and multiple myeloma. |
| 偶联 | APC |
| 其他可选修饰符 | Unconjugated/FITC/HRP/PE |
| 可提供抗体种类 | 5 |
| 免疫原 | Recombinant Human PLAUR/CD87 Protein (TMPY-02141) |
| 抗原种属 | Human |
| 研究领域 | Serine Proteases and Regulators |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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