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Anti-Tryptophan Hydroxylase 1/TPH-1 Antibody (9H209)
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产品编号 TMAC-04142
别名 tryptophan hydroxylase 1, TRPH, TPRH
Anti-Tryptophan Hydroxylase 1/TPH-1 Antibody (9H209) 是一种 Rabbit 抗体，靶向 Tryptophan Hydroxylase 1/TPH-1。Anti-Tryptophan Hydroxylase 1/TPH-1 Antibody (9H209) 可用于 WB,ICC/IF,IHC,IP,FCM。
Anti-Tryptophan Hydroxylase 1/TPH-1 Antibody (9H209)
Anti-Tryptophan Hydroxylase 1/TPH-1 Antibody (9H209)
还可以产品编号 TMAC-04142 别名 tryptophan hydroxylase 1, TRPH, TPRH
Anti-Tryptophan Hydroxylase 1/TPH-1 Antibody (9H209) 是一种 Rabbit 抗体，靶向 Tryptophan Hydroxylase 1/TPH-1。Anti-Tryptophan Hydroxylase 1/TPH-1 Antibody (9H209) 可用于 WB,ICC/IF,IHC,IP,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,485 | 5日内发货 |
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化学信息
| 产品描述 | Anti-Tryptophan Hydroxylase 1/TPH-1 Antibody (9H209) is a Rabbit antibody targeting Tryptophan Hydroxylase 1/TPH-1. Anti-Tryptophan Hydroxylase 1/TPH-1 Antibody (9H209) can be used in WB,ICC/IF,IHC,IP,FCM. |
| 别名 | tryptophan hydroxylase 1, TRPH, TPRH |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-TPH1 antibody. Counter stained with hematoxylin. 2. Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue using anti-TPH1 antibody. Counter stained with hematoxylin. 3. Flow cytometric analysis of Hela cells with TPH1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| 应用 | |
| 推荐剂量 | WB: 1:1000; IHC: 1:50-200; ICC/IF: 1:50-200; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) comprise a small family of monooxygenases that use tetrahydropterine as a cofactor during the catabolism of aromatic L-amino acids. PAH, TH and TPH all contain catalytic domains with an amino-terminal regulatory domain and a short carboxy-terminal tetramerization domain. Each of these enzymes also contains a single ferrous iron atom, which is bound to two histidines and a glutamate and is likely to be involved in the formation of the hydroxylating intermediate. TPH is the first and rate-limiting step in the biosynthesis of serotonin in the central nervous system and melatonin in the pineal gland. Alteration of TPH function may be a key factor in the pathology of several neuropsychiatric disorders associated with serotonin, including depression, aggression, alcoholism and schizophrenia. For instance, L-DOPA, which is used as a common therapy for Parkinson??s disease (PD) patients, inhibits TPH function, which subsequently, is thought to contribute to the onset of depression in PD patients. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 51 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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