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顶部生物活性储存和溶解信息计算器

Anti-Tryptophan Hydroxylase 1/TPH-1 Antibody (9H209)

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产品编号 TMAC-04142

别名 tryptophan hydroxylase 1, TRPH, TPRH

Anti-Tryptophan Hydroxylase 1/TPH-1 Antibody (9H209) 是一种 Rabbit 抗体，靶向 Tryptophan Hydroxylase 1/TPH-1。Anti-Tryptophan Hydroxylase 1/TPH-1 Antibody (9H209) 可用于 FCM,ICC/IF,IHC,IP,WB。

Anti-Tryptophan Hydroxylase 1/TPH-1 Antibody (9H209)

Anti-Tryptophan Hydroxylase 1/TPH-1 Antibody (9H209)

一键复制产品信息
Rating icon 还可以
产品编号 TMAC-04142 别名 tryptophan hydroxylase 1, TRPH, TPRH

Anti-Tryptophan Hydroxylase 1/TPH-1 Antibody (9H209) 是一种 Rabbit 抗体，靶向 Tryptophan Hydroxylase 1/TPH-1。Anti-Tryptophan Hydroxylase 1/TPH-1 Antibody (9H209) 可用于 FCM,ICC/IF,IHC,IP,WB。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,485
5日内发货
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产品介绍

生物活性
产品描述
Anti-Tryptophan Hydroxylase 1/TPH-1 Antibody (9H209) is a Rabbit antibody targeting Tryptophan Hydroxylase 1/TPH-1. Anti-Tryptophan Hydroxylase 1/TPH-1 Antibody (9H209) can be used in FCM,ICC/IF,IHC,IP,WB.
别名tryptophan hydroxylase 1, TRPH, TPRH
Ig Type
IgG
克隆号
9H209
交叉反应
Human,Mouse,Rat
验证活性
1. Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-TPH1 antibody. Counter stained with hematoxylin.
2. Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue using anti-TPH1 antibody. Counter stained with hematoxylin.
3. Flow cytometric analysis of Hela cells with TPH1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
verifiedActivityverifiedActivityverifiedActivity
应用FCMICC/IFIHCIPWB
推荐剂量
WB: 1:1000; IHC: 1:50-200; ICC/IF: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) comprise a small family of monooxygenases that use tetrahydropterine as a cofactor during the catabolism of aromatic L-amino acids. PAH, TH and TPH all contain catalytic domains with an amino-terminal regulatory domain and a short carboxy-terminal tetramerization domain. Each of these enzymes also contains a single ferrous iron atom, which is bound to two histidines and a glutamate and is likely to be involved in the formation of the hydroxylating intermediate. TPH is the first and rate-limiting step in the biosynthesis of serotonin in the central nervous system and melatonin in the pineal gland. Alteration of TPH function may be a key factor in the pathology of several neuropsychiatric disorders associated with serotonin, including depression, aggression, alcoholism and schizophrenia. For instance, L-DOPA, which is used as a common therapy for Parkinson??s disease (PD) patients, inhibits TPH function, which subsequently, is thought to contribute to the onset of depression in PD patients.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
P17752
化学信息
分子量Theoretical: 51 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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