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Anti-TRXR1/TXNRD1 Antibody (5M66)
还可以产品编号 TMAY-02474
Anti-TRXR1/TXNRD1 Antibody (5M66) 是一种 Mouse 抗体，靶向 TRXR1/TXNRD1。Anti-TRXR1/TXNRD1 Antibody (5M66) 可用于 FCM,ICC/IF。
Anti-TRXR1/TXNRD1 Antibody (5M66)
Anti-TRXR1/TXNRD1 Antibody (5M66)
还可以产品编号 TMAY-02474
Anti-TRXR1/TXNRD1 Antibody (5M66) 是一种 Mouse 抗体，靶向 TRXR1/TXNRD1。Anti-TRXR1/TXNRD1 Antibody (5M66) 可用于 FCM,ICC/IF。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-TRXR1/TXNRD1 Antibody (5M66) is a Mouse antibody targeting TRXR1/TXNRD1. Anti-TRXR1/TXNRD1 Antibody (5M66) can be used in FCM,ICC/IF. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 5M66 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunofluorescence staining of Human TXNRD1 in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with mouse anti-Human TXNRD1 monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-mouse IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cytoplasm and nucleus. 2. Flow cytometric analysis of Human TXNRD1 expression on HeLa cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human C1QBP, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM,ICC/IF |
| 推荐剂量 | ICC-IF: 1:20-1:100; FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This product is a recombinant monoclonal antibody expressed from HEK293 cells. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidative damage. We investigated the association between TXNRD1 polymorphisms and ATDH susceptibility. Moreover, TXNRD1 is an essential selenium-containing enzyme involved in detoxification of reactive oxygen species (ROS) and redox signaling. And genetic variations in TXNRD1 favor the development of Drug-induced liver injury (DILI), which is the most common adverse drug reaction. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human TXNRD1 protein (TMPY-02271) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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