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Anti-Transferrin Receptor/TFRC Antibody (5H415) 是一种 Mouse 抗体,靶向 Transferrin Receptor/TFRC。Anti-Transferrin Receptor/TFRC Antibody (5H415) 可用于 FCM。
Anti-Transferrin Receptor/TFRC Antibody (5H415) 是一种 Mouse 抗体,靶向 Transferrin Receptor/TFRC。Anti-Transferrin Receptor/TFRC Antibody (5H415) 可用于 FCM。
产品描述 | Anti-Transferrin Receptor/TFRC Antibody (5H415) is a Mouse antibody targeting Transferrin Receptor/TFRC. Anti-Transferrin Receptor/TFRC Antibody (5H415) can be used in FCM. |
Ig Type | Monoclonal Mouse IgG1 |
克隆号 | 5H415 |
交叉反应 | Human |
验证活性 | Flow cytometric analysis of Human TFRC(CD71) expression on U937 cells. Cells were stained with purified anti-Human TFRC(CD71), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
应用 | FCM |
推荐剂量 | FCM: 1:25-1:100 |
抗体种类 | Monoclonal |
宿主来源 | Mouse |
构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Transferrin Receptor / TFRC / CD71 (rh Transferrin Receptor / TFRC / CD71; TMPY-01873; AAA61153.1; Cys89-Phe760). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | 0.2 μm filtered solution in PBS |
研究背景 | Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p9, CD71 and TFRC, is a single-pass type II membrane protein that belongs to the peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target. |
偶联 | Unconjugated |
其他可选修饰符 | APC/PerCP/FITC/PE |
可提供抗体种类 | 5 |
免疫原 | Recombinant Human Transferrin Receptor / TFRC / CD71 Protein (TMPY-01873) |
抗原种属 | Human |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
运输方式 | Shipping with blue ice. |
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