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Anti-SARS-CoV-2 Spike RBD Nanobody Antibody-FITC (5A563)
还可以产品编号 TMAH-01070F
别名 Spike glycoprotein, S glycoprotein, Peplomer protein, E2
Anti-SARS-CoV-2 Spike RBD Nanobody Antibody-FITC (5A563) 是一种 FITC-conjugated 抗体，靶向 SARS-CoV-2 Spike RBD Nanobody。Anti-SARS-CoV-2 Spike RBD Nanobody Antibody-FITC (5A563) 可用于 。
Anti-SARS-CoV-2 Spike RBD Nanobody Antibody-FITC (5A563)
Anti-SARS-CoV-2 Spike RBD Nanobody Antibody-FITC (5A563)
还可以产品编号 TMAH-01070F 别名 Spike glycoprotein, S glycoprotein, Peplomer protein, E2
Anti-SARS-CoV-2 Spike RBD Nanobody Antibody-FITC (5A563) 是一种 FITC-conjugated 抗体，靶向 SARS-CoV-2 Spike RBD Nanobody。Anti-SARS-CoV-2 Spike RBD Nanobody Antibody-FITC (5A563) 可用于 。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 3,070 | 5日内发货 | |
| 100 μL | ¥ 5,270 | 5日内发货 |
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-SARS-CoV-2 Spike RBD Nanobody Antibody-FITC (5A563) is a FITC-conjugated antibody targeting SARS-CoV-2 Spike RBD Nanobody. Anti-SARS-CoV-2 Spike RBD Nanobody Antibody-FITC (5A563) can be used in . |
| 别名 | Spike glycoprotein, S glycoprotein, Peplomer protein, E2 |
| Ig Type | VHH fusion with human IgG1 Fc |
| 克隆号 | 5A563 |
| 交叉反应 | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) |
| 应用 | ELISA |
| 推荐剂量 | ELISA:1:10000-1:50000. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| 研究背景 | attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein. Binding to host NRP1 and NRP2 via C-terminal polybasic sequence enhances virion entry into host cell. This interaction may explain virus tropism of human olfactory epithelium cells, which express high level of NRP1 and NRP2 but low level of ACE2. The stalk domain of S contains three hinges, giving the head unexpected orientational freedom. Uses human TMPRSS2 for priming in human lung cells which is an essential step for viral entry. Can be alternatively processed by host furin. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes. mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis. May down-regulate host tetherin (BST2) by lysosomal degradation, thereby counteracting its antiviral activity. |
| 偶联 | FITC |
| 其他可选修饰符 | Unconjugated/Biotin/HRP |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Protein: Human Novel Coronavirus Spike glycoProtein(S) (319-541aa) |
| 抗原种属 | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) |
| Uniprot ID | |
| 研究领域 | Microbiology |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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