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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-RNF4 Antibody (7S6)

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货号 TMAB-12321

Anti-RNF4 Antibody (7S6) 是一种 Mouse 抗体，靶向 RNF4。Anti-RNF4 Antibody (7S6) 可用于 WB。

Anti-RNF4 Antibody (7S6)

Anti-RNF4 Antibody (7S6)

一键复制产品信息
Rating icon 还可以
货号 TMAB-12321

Anti-RNF4 Antibody (7S6) 是一种 Mouse 抗体，靶向 RNF4。Anti-RNF4 Antibody (7S6) 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,960
5日内发货
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产品介绍

生物活性
产品描述
Anti-RNF4 Antibody (7S6) is a Mouse antibody targeting RNF4. Anti-RNF4 Antibody (7S6) can be used in WB.
Ig Type
IgG1, k
克隆号
7S6
反应种属
Human
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome. Note=Enriched in stage I melanosomes.
组织特异性Widely expressed at low levels in many tissues; highly expressed in testis.
构建方式Hybridoma Monoclonal Antibody
纯化方式Protein G purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The Ras-related superfamily of guanine nucleotide binding proteins, which includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies, exhibit 30-60% homology with Ras p21. Accumulating data suggests an important role for Rab proteins, either in endocytosis or in biosynthetic protein transport. The transport of newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves at each stage the movement of carrier vesicles, a process that appears to involve Rab protein function. The possibility that Rab proteins might also direct the exocytosis from secretory vesicles to the plasma membrane is supported by the observation that in yeast, the SEC4 protein, which is 40% homologous to Rab proteins, is associated with secretory vesicles. At least eight members of the Rab subfamily have been identified, each of which is found at a particular stage of a membrane transport pathway.
抗原信息
免疫原
Recombinant Protein: human RNF4
抗原种属
Human
基因名称
RNF4
基因ID
5869
蛋白名称
E3 ubiquitin-protein ligase RNF4
Uniprot ID
P61020
功能
Rab5b is a member of the Rab family of small (monomeric) G proteins. Like other small G proteins, Rab5b switches between an inactive, GDP-form and an active, GTP-bound form. GDP/GTP exchange factors (GEFs) catalyse the conversion from the GDP-bound form to the GTP-bound form, while GTPase-activating proteins (GAPs) catalyse GTP hydrolysis to GDP. Rab5b is involved in endocytosis and recycling of cell surface molecules. It interacts with RIN2 and RIN3, which regulate its function, possibly by acting as GEFs. Knockdown of Rab5b abolished group I metabotropic glutamate receptor (mGluR)-mediated neuroprotection. Furthermore, Rab5b interacts with LRRK2, the defective gene at the PARK8 locus that results in Parkinson's disease. Roles for Rab5b in neurodegenerative disease, neuroprotection, and synaptic plasticity have been suggested.
化学信息
分子量Theoretical: 21 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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