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Anti-PPM1A Antibody-PE (9X611)
还可以产品编号 TMAY-02428P
Anti-PPM1A Antibody-PE (9X611) 是一种 PE-conjugated Mouse 抗体，靶向 PPM1A。Anti-PPM1A Antibody-PE (9X611) 可用于 FCM。
Anti-PPM1A Antibody-PE (9X611)
Anti-PPM1A Antibody-PE (9X611)
还可以产品编号 TMAY-02428P
Anti-PPM1A Antibody-PE (9X611) 是一种 PE-conjugated Mouse 抗体，靶向 PPM1A。Anti-PPM1A Antibody-PE (9X611) 可用于 FCM。
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偶联与修饰
抗原信息
| 产品描述 | Anti-PPM1A Antibody-PE (9X611) is a PE-conjugated Mouse antibody targeting PPM1A. Anti-PPM1A Antibody-PE (9X611) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 9X611 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human PPM1A expression in Jurkat cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with PE Mouse anti-Human PPM1A. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PPM1A / PP2C-alpha (rh PPM1A / PP2C-alpha; TMPY-02567; P35813-1; Met1-Trp382) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | Protein phosphatase 1A (PPM1A / PP2CA) is an enzyme belonging to the PP2C family of Ser / Thr protein phosphatases. Members of PP2C family are negative regulators of cell stress response pathways and the MAP kinases and MAP kinase kinases. It has also been demonstrated to inhibit the activation of p38 and JNK kinase cascades. PPM1A dephosphorylates and promotes nuclear export of TGFβ-activated Smad2/3. Ectopic expression of PPM1A abolishes TGFβ-induced antiproliferative and transcriptional responses, whereas depletion of PPM1A enhances TGFβ signaling in mammalian cells. It has been demonstrated that PPM1A / PP2CA, through dephosphorylation of Smad2/3, plays a critical role in terminating TGFβ signaling. Overexpression of PPM1A is reported to activate the expression of the tumor suppressor gene TP53 / p53, which leads to cell apoptosis. |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated/FITC |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Human PPM1A / PP2C-alpha protein (TMPY-02567) |
| 抗原种属 | Human |
| 研究领域 | Phosphatases and Regulators |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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