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顶部生物活性储存和溶解信息计算器

Anti-PKN1 Antibody (9Q867)

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Anti-PKN1 Antibody (9Q867)
产品编号 TMAC-03354
别名 Serine-threonine protein kinase N, Serine/threonine-protein kinase N1, Protein-kinase C-related kinase 1, Protein kinase PKN-alpha, Protein kinase C-like PKN, Protein kinase C-like 1, Protease-activated kinase 1 (PAK-1), PRKCL1, PRK1, PKN1, PKN, PAK1

Anti-PKN1 Antibody (9Q867) 是一种 Mouse 抗体，靶向 PKN1。Anti-PKN1 Antibody (9Q867) 可用于 WB,IHC,ICC,FCM。

Anti-PKN1 Antibody (9Q867)

Anti-PKN1 Antibody (9Q867)

Rating icon 还可以
Anti-PKN1 Antibody (9Q867)
产品编号 TMAC-03354 别名 Serine-threonine protein kinase N, Serine/threonine-protein kinase N1, Protein-kinase C-related kinase 1, Protein kinase PKN-alpha, Protein kinase C-like PKN, Protein kinase C-like 1, Protease-activated kinase 1 (PAK-1), PRKCL1, PRK1, PKN1, PKN, PAK1

Anti-PKN1 Antibody (9Q867) 是一种 Mouse 抗体，靶向 PKN1。Anti-PKN1 Antibody (9Q867) 可用于 WB,IHC,ICC,FCM。

规格价格库存数量
50 μL
¥ 1,990
5日内发货
100 μL
¥ 2,990
5日内发货
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产品介绍

生物活性
产品描述
Anti-PKN1 Antibody (9Q867) is a Mouse antibody targeting PKN1. Anti-PKN1 Antibody (9Q867) can be used in WB,IHC,ICC,FCM.
别名Serine-threonine protein kinase N, Serine/threonine-protein kinase N1, Protein-kinase C-related kinase 1, Protein kinase PKN-alpha, Protein kinase C-like PKN, Protein kinase C-like 1, Protease-activated kinase 1 (PAK-1), PRKCL1, PRK1, PKN1, PKN, PAK1
交叉反应
Human
验证活性
1. Western blot analysis of PKN1 on human PKN1 recombinant protein using anti-PKN1 antibody at 1/1,000 dilution.
2. Western blot analysis of PKN1 on HEK293 (1) and PKN1-hIgGFc transfected HEK293 (2) cell lysate using anti-PKN1 antibody at 1/1,000 dilution.
3. Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-PKN1 antibody. Counter stained with hematoxylin.
4. ICC staining PKN1 (green) and Actin filaments (red) in Hela cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
5. Flow cytometric analysis of Hela cells with PKN1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).
应用
WB
IHC
ICC
FCM
推荐剂量
WB: 1:500-2000; IHC: 1:50-200; ICC: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Rho, the Ras-related small GTPase, is responsible for the regulation of actin-based cytoskeletal structures including stress fibers, focal adhesions and the contractile ring apparatus. Rho proteins act as molecular switches which are able to turn cytokinesis on and off. Although little is know about signaling downstream of Rho, several proteins have been implicated as Rho effectors. Protein kinase N (PKN) is a fatty acid-activated serine/threonine kinase whose catalytic domain exhibits homology with that of the PKC family. PKN associates with Rho via its amino terminus, is activated in a GTP-dependent manner and phosphorylates the head-rod domain of neurofilament protein. A second protein, rhophilin, exhibits 40% sequence identity with the amino terminal Rho binding domain. The enzymatic activity of rhophilin has not been demonstrated and it is possible that it acts through the recruitment of cytoskeletal components that initiate a kinase signaling cascade. Citron interacts specifically with active Rho and Rac1 but not Cdc42. Citron exhibits a distinctive protein organization and little homology with the Rho binding domains of PKN and rhophilin.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
Q16512
化学信息
分子量Theoretical: 104 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

Protein kinase PKN-αProtein kinase PKN-aPRKCL 1PRK 1PKN 1PAK-1PAK 1

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