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顶部生物活性储存和溶解信息计算器

Anti-Phospho-TAK1(Thr184+Thr187) Polyclonal Antibody

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产品编号 TMAB-11337

种类：Rabbit Polyclonal
应用：IHC-P,IHC-Fr,IF
交叉反应：Rat (predicted:Human,Mouse,Chicken,Pig,Cow,Horse,Rabbit)

Anti-Phospho-TAK1(Thr184+Thr187) Polyclonal Antibody

Anti-Phospho-TAK1(Thr184+Thr187) Polyclonal Antibody

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Rating icon 还可以
产品编号 TMAB-11337

种类：Rabbit Polyclonal
应用：IHC-P,IHC-Fr,IF
交叉反应：Rat (predicted:Human,Mouse,Chicken,Pig,Cow,Horse,Rabbit)

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产品介绍

生物活性
产品描述
Anti-Phospho-TAK1(Thr184+Thr187) Polyclonal Antibody is a Rabbit antibody targeting Phospho-TAK1(Thr184+Thr187). Anti-Phospho-TAK1(Thr184+Thr187) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
交叉反应
Rat (predicted:Human,Mouse,Chicken,Pig,Cow,Horse,Rabbit)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:50-1000; IHC-Fr: 1:50-1000; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Although the majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is also localized at the cell membrane.
组织特异性Isoform 1A is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells. Isoform 1B is highly expressed in brain, kidney and small intestine. Isoform 1C is the major form in prostate. Isoform 1D is the less abundant form.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human TAK1 around the phosphorylation site of Thr184/187
抗原种属
Human
基因名称
MAP3K7
基因ID
6885
蛋白名称
Mitogen-activated protein kinase kinase kinase 7
Uniprot ID
O43318
功能
Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B.
化学信息
分子量Theoretical: 67 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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