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Anti-Phospho-MST4+MST3+STK25 (Thr178+Thr190+Thr174) Polyclonal Antibody

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货号 TMAB-11013

Anti-Phospho-MST4+MST3+STK25 (Thr178+Thr190+Thr174) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-MST4+MST3+STK25 (Thr178+Thr190+Thr174)。Anti-Phospho-MST4+MST3+STK25 (Thr178+Thr190+Thr174) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Phospho-MST4+MST3+STK25 (Thr178+Thr190+Thr174) Polyclonal Antibody

Anti-Phospho-MST4+MST3+STK25 (Thr178+Thr190+Thr174) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-11013

Anti-Phospho-MST4+MST3+STK25 (Thr178+Thr190+Thr174) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-MST4+MST3+STK25 (Thr178+Thr190+Thr174)。Anti-Phospho-MST4+MST3+STK25 (Thr178+Thr190+Thr174) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

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产品描述
Anti-Phospho-MST4+MST3+STK25 (Thr178+Thr190+Thr174) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MST4+MST3+STK25 (Thr178+Thr190+Thr174). Anti-Phospho-MST4+MST3+STK25 (Thr178+Thr190+Thr174) Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Cow,Horse,Sheep)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位STK25, MST4: Cytoplasmic, Golgi Apparatus. MST3: Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Co-localizes with STK38L in the membrane.
组织特异性MST3: Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Novel human Ste20-related kinase Mst4 is biologically active in the activation of MEK/ERK pathway and in mediating cell growth and transformation. It is pro apoptotic and is highly expressed in placenta, thymus, and peripheral blood leukocytes. Interaction with Golgi matrix protein GOLGA2 results in autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. This may also be activated by C terminal cleavage. MST3 or Mammalian Sterile 20-like kinase 3 is a member of the germinal center kinase-III family. MST3 contains a conserved kinase domain at its NH(2)-terminus and a regulatory domain at its COOH-terminus. Caspase-mediated cleavage of the regulatory domain of MST3 activates its intrinsic kinase activity and leads to nuclear translocation. Expression of COOH-terminal truncated MST3 in cells results in DNA fragmentation and induction of apoptosis. It can inhibit cell migration in a fashion dependent on autophosphorylation and can regulate paxillin phosphorylation through tyrosine phosphatase PTP-PEST. Mitogen activated protein kinase cascades have been conserved throughout evolution. In mammals, these cascades allow responses to complex stimuli such as growth factors and inflammatory cytokines. In yeast, STK25 functions upstream of the MAPK cascade.
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human MST4/MST3/STK25 around the phosphorylation site of Thr178/Thr190/Thr174
抗原种属
Human
基因名称
STK25
基因ID
10494
蛋白名称
Serine/threonine-protein kinase 25
Uniprot ID
O00506
功能
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
化学信息
分子量Theoretical: 48 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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