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Anti-Phospho-IRF3 (Ser386) Polyclonal Antibody 2

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Anti-Phospho-IRF3 (Ser386) Polyclonal Antibody 2
产品编号 TMAC-02218
别名 p-IRF3 (Ser386), p-IRF3 (S386), IRF3 (p-Ser386), IRF3 (p-S386)

Anti-Phospho-IRF3 (Ser386) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-IRF3 (Ser386)。Anti-Phospho-IRF3 (Ser386) Polyclonal Antibody 可用于 WB。

Anti-Phospho-IRF3 (Ser386) Polyclonal Antibody 2

Anti-Phospho-IRF3 (Ser386) Polyclonal Antibody 2

Rating icon 还可以
Anti-Phospho-IRF3 (Ser386) Polyclonal Antibody 2
产品编号 TMAC-02218 别名 p-IRF3 (Ser386), p-IRF3 (S386), IRF3 (p-Ser386), IRF3 (p-S386)

Anti-Phospho-IRF3 (Ser386) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-IRF3 (Ser386)。Anti-Phospho-IRF3 (Ser386) Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,480
5日内发货
100 μL
¥ 2,245
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-IRF3 (Ser386) Polyclonal Antibody is a Rabbit antibody targeting Phospho-IRF3 (Ser386). Anti-Phospho-IRF3 (Ser386) Polyclonal Antibody can be used in WB.
别名p-IRF3 (Ser386), p-IRF3 (S386), IRF3 (p-Ser386), IRF3 (p-S386)
Ig Type
IgG
交叉反应
Human
验证活性
1. Western blot analysis of extracts from untreated and treated 293T cell lysate using IRF-3 (Phospho-Ser386) Antibody TMAC-02218 at 1/500 dilution.
应用
WB
推荐剂量
WB: 1:500-1000
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of Serine 386(A-S-S(p)-L-E) derived from Human IRF-3
抗原种属
human
Uniprot ID
Q14653
化学信息
分子量Actual: 55 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

pIRF3 (Ser386)pIRF3 (S386)IRF3 (pSer386)IRF3 (pS386)IRF3 (phospho-Ser386)IRF3 (phospho-S386)

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4个月前
5.0
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