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顶部生物活性储存和溶解信息计算器

Anti-Phospho-Histone H3 (Ser28) Polyclonal Antibody 2

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产品编号 TMAB-10799

种类：Rabbit Polyclonal
应用：FCM
交叉反应：Human (predicted:Mouse,Rat,Pig,Cow,Rabbit,Fruit Fly)

Anti-Phospho-Histone H3 (Ser28) Polyclonal Antibody 2

Anti-Phospho-Histone H3 (Ser28) Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-10799

种类：Rabbit Polyclonal
应用：FCM
交叉反应：Human (predicted:Mouse,Rat,Pig,Cow,Rabbit,Fruit Fly)

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产品介绍

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产品描述
Anti-Phospho-Histone H3 (Ser28) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-Histone H3 (Ser28). Anti-Phospho-Histone H3 (Ser28) Polyclonal Antibody 2 can be used in FCM.
Ig Type
IgG
交叉反应
Human (predicted:Mouse,Rat,Pig,Cow,Rabbit,Fruit Fly)
应用FCM
推荐剂量
FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Chromosome. Note=Localizes to both the large, transcriptionally active, somatic macronucleus (MAC) and the small, transcriptionally inert, germ line micronucleus (MIC).
组织特异性Expressed in testicular cells.Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. The N-terminal tail of core histones undergoes different posttranslational modifications including acetylation, phosphorylation and methylation. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression. In most species, the histone H2B is primarily acetylated at lysines 5, 12, 15 and 20. Histone H3 is primarily acetylated at lysines 9, 14, 18 and 23. Acetylation at lysine 9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis.
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human Histone H3 around the phosphorylation site of Ser28
抗原种属
Human
基因名称
H3C1
基因ID
8350
蛋白名称
Histone H3.1
Uniprot ID
P68431
功能
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. H3 is deposited into chromatin exclusively through a DNA replication-coupled pathway that can be associated with either DNA duplication or DNA repair synthesis during meiotic homologous recombination.
化学信息
分子量Theoretical: 15 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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4个月前
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