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顶部生物活性储存和溶解信息计算器

Anti-Phospho-FoxO3a (Ser253) Antibody (7R176)

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产品编号 TMAB-10714

种类：Recombinant Rabbit Monoclonal
应用：WB,IHC-P,IHC-Fr,IF
交叉反应：Human,Mouse,Rat

Anti-Phospho-FoxO3a (Ser253) Antibody (7R176)

Anti-Phospho-FoxO3a (Ser253) Antibody (7R176)

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-10714

种类：Recombinant Rabbit Monoclonal
应用：WB,IHC-P,IHC-Fr,IF
交叉反应：Human,Mouse,Rat

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产品介绍

生物活性
产品描述
Anti-Phospho-FoxO3a (Ser253) Antibody (7R176) is a Rabbit antibody targeting Phospho-FoxO3a (Ser253). Anti-Phospho-FoxO3a (Ser253) Antibody (7R176) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
克隆号
7R176
交叉反应
Human,Mouse,Rat
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus upon oxidative stress and in the absence of survival factors. Tissue Specificity : Ubiquitous.
组织特异性Ubiquitous.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
抗原信息
免疫原
A synthesized peptide: human FOXO3A around the phosphorylation site of S253
抗原种属
Human
基因名称
FOXO3
基因ID
2309
蛋白名称
Forkhead box protein O3
Uniprot ID
O43524
功能
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
化学信息
分子量Theoretical: 71 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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