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Anti-NUMA1 Antibody (4G738)
还可以产品编号 TMAH-00838
别名 SP-H antigen, NuMA protein, NUMA 1, NUMA, Nuclear mitotic apparatus protein 1, Nuclear mitotic apparatus protein, Nuclear matrix protein-22, NMP-22, NMP22
Anti-NUMA1 Antibody (4G738) 是一种抗体，靶向 NUMA1。Anti-NUMA1 Antibody (4G738) 可用于 ELISA, FC。
Anti-NUMA1 Antibody (4G738)
Anti-NUMA1 Antibody (4G738)
还可以产品编号 TMAH-00838 别名 SP-H antigen, NuMA protein, NUMA 1, NUMA, Nuclear mitotic apparatus protein 1, Nuclear mitotic apparatus protein, Nuclear matrix protein-22, NMP-22, NMP22
Anti-NUMA1 Antibody (4G738) 是一种抗体，靶向 NUMA1。Anti-NUMA1 Antibody (4G738) 可用于 ELISA, FC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,300 | 5日内发货 | |
| 100 μL | ¥ 2,195 | 5日内发货 |
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产品介绍
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抗原信息
| 产品描述 | Anti-NUMA1 Antibody (4G738) is an antibody targeting NUMA1. Anti-NUMA1 Antibody (4G738) can be used in ELISA, FC. |
| 别名 | SP-H antigen, NuMA protein, NUMA 1, NUMA, Nuclear mitotic apparatus protein 1, Nuclear mitotic apparatus protein, Nuclear matrix protein-22, NMP-22, NMP22 |
| Ig Type | Rabbit IgG |
| 克隆号 | 4G738 |
| 交叉反应 | Human |
| 验证活性 | Overlay Peak curve showing Hela cells stained with TMAH-00838 (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1µg/1*10^6 cells) for 45min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4°C.Control antibody (green line) was rabbit IgG (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| 应用 | ELISA, FC |
| 推荐剂量 | FC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Nucleus. Nucleus, nucleoplasm. Nucleus matrix. Chromosome. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cell cortex. Cell membrane; Lipid-anchor; Cytoplasmic side. Lateral cell membrane.; [Isoform 3]: Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.; [Isoform 4]: Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division. Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles. Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner. In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle. During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation. Binds also to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro. Also required for proper orientation of the mitotic spindle during asymmetric cell divisions. Plays a role in mitotic MT aster assembly. Involved in anastral spindle assembly. Positively regulates TNKS protein localization to spindle poles in mitosis. Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume. Required for epidermal differentiation and hair follicle morphogenesis. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human NUMA1 |
| 抗原种属 | Human |
| 基因ID | 4926 |
| Uniprot ID | |
| 研究领域 | Cell biology |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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