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Anti-NME1 Antibody-PE (1U277)
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产品编号 TMAY-01935P
别名 NME/NM23 nucleoside diphosphate kinase 1, NM23-H1, NM23, NDPK-A, NDPKA, NDKA, NBS, NB, GAAD, AWD
Anti-NME1 Antibody-PE (1U277) 是一种 PE-conjugated Mouse 抗体，靶向 NME1。Anti-NME1 Antibody-PE (1U277) 可用于 FCM。
Anti-NME1 Antibody-PE (1U277)
331 Anti-NME1 Antibody-PE (1U277)
还可以产品编号 TMAY-01935P 别名 NME/NM23 nucleoside diphosphate kinase 1, NM23-H1, NM23, NDPK-A, NDPKA, NDKA, NBS, NB, GAAD, AWD
Anti-NME1 Antibody-PE (1U277) 是一种 PE-conjugated Mouse 抗体，靶向 NME1。Anti-NME1 Antibody-PE (1U277) 可用于 FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 T | ¥ 1,090 | 5日内发货 | |
| 100 T | ¥ 2,185 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-NME1 Antibody-PE (1U277) is a PE-conjugated Mouse antibody targeting NME1. Anti-NME1 Antibody-PE (1U277) can be used in FCM. |
| 别名 | NME/NM23 nucleoside diphosphate kinase 1, NM23-H1, NM23, NDPK-A, NDPKA, NDKA, NBS, NB, GAAD, AWD |
| Ig Type | Mouse IgG1 |
| 克隆号 | 1U277 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human NME1 expression in HeLa cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with PE Mouse anti-NME1. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human NME1 / NDKA (rh NME1 / NDKA; TMPY-04467; NP_000260.1; Ala 2-Glu 152) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | NME1, also known as Nucleoside Diphosphate Kinase A (NDK-A), or NM23-H1, belongs to the NDK family. NM23-H1 is known to have a metastasis suppressive activity in many tumor cells. Recent studies have shown that the interacting proteins with NM23-H1 which mediate cell proliferation, may act as modulators of the metastasis suppressor activity. The interacting proteins with NM23-H1 can be classified into 3 groups. The first group of proteins can be classified as upstream kinases of NM23-H1 such as CKI and Aurora-A/STK15. The second group of proteins acts as downstream effectors for the regulation of specific gene transcriptions, GTP-binding protein functions, and signal transduction in the Erk signal cascade. The third group of proteins can be classified as bi-directionally influencing binding partners of NM23-H1. As a result, the interactions with NM23-H1 and binding partners have implications in the biochemical characterization involved in metastasis and tumorigenesis. NDKA is increased in human postmortem cerebrospinal fluid (CSF), a model of global brain insult, suggesting that measurement in CSF and, more importantly, in plasma may be useful as a biomarker of stroke. Additionally, NM23-H1 significantly reduces metastasis without effects on primary tumor size and was the first discovered metastasis suppressor gene. |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated/FITC |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Protein: Human NME1 / NDKA protein (TMPY-04467) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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