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Anti-MFN1 Polyclonal Antibody

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Anti-MFN1 Polyclonal Antibody
产品编号 TMAB-01131

Anti-MFN1 Polyclonal Antibody 是一种 Rabbit 抗体,靶向 MFN1。Anti-MFN1 Polyclonal Antibody 可用于 FCM。

Anti-MFN1 Polyclonal Antibody

Anti-MFN1 Polyclonal Antibody

Rating icon 还可以
Anti-MFN1 Polyclonal Antibody
产品编号 TMAB-01131

Anti-MFN1 Polyclonal Antibody 是一种 Rabbit 抗体,靶向 MFN1。Anti-MFN1 Polyclonal Antibody 可用于 FCM。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-MFN1 Polyclonal Antibody is a Rabbit antibody targeting MFN1. Anti-MFN1 Polyclonal Antibody can be used in FCM.
Ig Type
IgG
交叉反应
Rat (predicted:Human,Mouse,Horse,Rabbit)
验证活性
Blank control: RSC96 (blue), the cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with ice-cold 90% methanol for 30 min on ice.
Isotype Control Antibody: Rabbit Igg (orange);
Secondary Antibody: Goat anti-rabbit IgG-Pe (white blue),
Dilution: 1:200 in 1 X PBS containing 0.5% BSA;
Primary Antibody Dilution: 1 μg in 100 μL 1X PBS containing 0.5% BSA (green).
应用
推荐剂量
FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm and Mitochondrion outer membrane.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究背景Mitofusin 1 (Mfn1) and mitofusin 2 (Mfn2) are homologs for the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins and are mediators of mitochondrial fusion. A GTPase domain is required for Mfn protein function but the molecular mechanisms of the GTPase-dependent reaction as well as the functional division of the two Mfn proteins are unknown. They are essential for embryonic development and may play a role in the pathobiology of obesity. Although the Mfn1 and Mfn2 genes are broadly expressed, they show different levels of expression in different tissues. Two Mfn1 transcripts are elevated in heart, while Mfn2 mRNA is abundantly expressed in heart and muscle tissue but present only at low levels in many other tissues. Mfn1 localizes to mitochondria and participates in at least two different high molecular weight protein complexes in a GTP-dependent manner. Purified recombinant Mfn1 exhibited approximately eightfold higher GTPase activity than Mfn2.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Mfn 1
抗原种属
Human
基因ID
Uniprot ID
研究领域
Mitochondrial markers,Mitophagy fission and fusion,Parkinson's disease,GTP,Mitochondria
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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