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Anti-MAPKAPK3 Antibody (5K175)
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产品编号 TMAY-01057
别名 MK-3, mitogen-activated protein kinase-activated protein kinase 3, MAPKAPK-3, MAPKAP-K3, MAPKAP3, 3PK
Anti-MAPKAPK3 Antibody (5K175) 是一种 Mouse 抗体，靶向 MAPKAPK3。Anti-MAPKAPK3 Antibody (5K175) 可用于 IHC-P。
Anti-MAPKAPK3 Antibody (5K175)
331 Anti-MAPKAPK3 Antibody (5K175)
还可以产品编号 TMAY-01057 别名 MK-3, mitogen-activated protein kinase-activated protein kinase 3, MAPKAPK-3, MAPKAP-K3, MAPKAP3, 3PK
Anti-MAPKAPK3 Antibody (5K175) 是一种 Mouse 抗体，靶向 MAPKAPK3。Anti-MAPKAPK3 Antibody (5K175) 可用于 IHC-P。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,679 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-MAPKAPK3 Antibody (5K175) is a Mouse antibody targeting MAPKAPK3. Anti-MAPKAPK3 Antibody (5K175) can be used in IHC-P. |
| 别名 | MK-3, mitogen-activated protein kinase-activated protein kinase 3, MAPKAPK-3, MAPKAP-K3, MAPKAP3, 3PK |
| Ig Type | Mouse IgG2a |
| 克隆号 | 5K175 |
| 交叉反应 | Human |
| 验证活性 | Immunochemical staining of human MAPKAPK3 in human skeletal muscle with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human MAPKAPK3/MK3 (rh MAPKAPK3/MK3; TMPY-04378; NP_004626.1; Met1-Gln382). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The MAPKAP kinases are a group of MAP kinase substrates that are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases that contain this motif have been identified and serve as substrates for the ERK and p38 MAP kinases. Mitogen-activated protein (MAP) kinase-activated protein kinase 3, also known as MAPKAPK-3 and 3pK, is a member of the Ser/Thr protein kinase family. It is widely expressed in human tissues, with a higher expression level observed in the heart and skeletal muscle. No expression in the brain. MAPKAPK-3 is unique since it was shown to be activated by three members of the MAPK family, namely extracellular-signal-regulated kinase (ERK), p38, and Jun-N-terminal kinase (JNK). It is highly activated both by mitogens and by stress-inducing agents or proinflammatory cytokines and translocates to the cytoplasm from the nucleus. MAPKAPK-3 is exclusively activated via the classical MAPK cascade, while stress-induced activation of MAPKAPK-3 is mainly mediated by p38, however, the mechanism defining the specificity remains unknown. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human MAPKAPK3/MK3 Protein (TMPY-04378) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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