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Anti-IL-6R Antibody-APC (5L295)
还可以产品编号 TMAY-00760A
Anti-IL-6R Antibody-APC (5L295) 是一种 APC-conjugated Mouse 抗体，靶向 IL-6R。Anti-IL-6R Antibody-APC (5L295) 可用于 FCM。
Anti-IL-6R Antibody-APC (5L295)
Anti-IL-6R Antibody-APC (5L295)
还可以产品编号 TMAY-00760A
Anti-IL-6R Antibody-APC (5L295) 是一种 APC-conjugated Mouse 抗体，靶向 IL-6R。Anti-IL-6R Antibody-APC (5L295) 可用于 FCM。
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抗原信息
| 产品描述 | Anti-IL-6R Antibody-APC (5L295) is a APC-conjugated Mouse antibody targeting IL-6R. Anti-IL-6R Antibody-APC (5L295) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 5L295 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human IL-6R expression on U266 cells. Cells were stained with APC-conjugated anti-Human IL-6R. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-6R / CD126 (rh IL-6R / CD126; TMPY-00864; NP_000556.1; Met1-Pro365). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a SIL-6R protein can mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signaling. Through this so-called 'trans-signaling' mechanism, IL-6 can stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and SIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | APC |
| 其他可选修饰符 | Unconjugated/FITC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human IL-6R / CD126 protein (TMPY-00864) |
| 抗原种属 | Human |
| 研究领域 | Neuroinflammation |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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