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Anti-IL-3R alpha/CD123 Antibody-APC (8N292)
还可以产品编号 TMAY-00941A
Anti-IL-3R alpha/CD123 Antibody-APC (8N292) 是一种 APC-conjugated Mouse 抗体，靶向 IL-3R alpha/CD123。Anti-IL-3R alpha/CD123 Antibody-APC (8N292) 可用于 FCM。
Anti-IL-3R alpha/CD123 Antibody-APC (8N292)
Anti-IL-3R alpha/CD123 Antibody-APC (8N292)
还可以产品编号 TMAY-00941A
Anti-IL-3R alpha/CD123 Antibody-APC (8N292) 是一种 APC-conjugated Mouse 抗体，靶向 IL-3R alpha/CD123。Anti-IL-3R alpha/CD123 Antibody-APC (8N292) 可用于 FCM。
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| 产品描述 | Anti-IL-3R alpha/CD123 Antibody-APC (8N292) is a APC-conjugated Mouse antibody targeting IL-3R alpha/CD123. Anti-IL-3R alpha/CD123 Antibody-APC (8N292) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2b |
| 克隆号 | 8N292 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human IL3RA expression on KG-1 cells. Cells were stained with APC-conjugated anti-Human IL3RA. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL3RA (rh IL3RA; TMPY-01410; NP_002174.1; Met1-Arg305) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 5 subfamily. The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. The WSXWS motif of IL3RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box one motif of IL3RA is required for JAK interaction and/or activation. IL3RA represents a unique marker for primitive leukemic stem cells. Targeting of IL3RA may be a promising strategy for the preferential ablation of AML cells. Aberrant IL3RA expression is a good marker for monitoring of minimal residual disease. IL3RA is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. Recent studies have shown that interleukin-3 receptor alpha (CD123) is highly expressed on leukemia stem cells of patients with acute myeloid leukemia, and is correlated with tumor load and poor prognosis. CD123 was highly expressed in the bone marrow of the patients with myelodysplastic syndrome (MDS), significantly correlated with the proportion of bone marrow blasts, and thus might be the marker of MDS malignant clone. IL3RA is also a useful new marker for distinguishing B-cell disorders with circulating villous lymphocytes as its expression is characteristic of typical hairy cell leukemia (HCL) with high sensitivity and specificity. |
| 偶联 | APC |
| 其他可选修饰符 | Unconjugated/FITC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human IL3RA Protein (TMPY-01410) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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