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Anti-IL-1RAP/IL-1RAcP Antibody (2C850)
还可以产品编号 TMAY-00302
别名 interleukin 1 receptor accessory protein
Anti-IL-1RAP/IL-1RAcP Antibody (2C850) 是一种 Mouse 抗体，靶向 IL-1RAP/IL-1RAcP。Anti-IL-1RAP/IL-1RAcP Antibody (2C850) 可用于 ELISA,FCM。
Anti-IL-1RAP/IL-1RAcP Antibody (2C850)
Anti-IL-1RAP/IL-1RAcP Antibody (2C850)
还可以产品编号 TMAY-00302 别名 interleukin 1 receptor accessory protein
Anti-IL-1RAP/IL-1RAcP Antibody (2C850) 是一种 Mouse 抗体，靶向 IL-1RAP/IL-1RAcP。Anti-IL-1RAP/IL-1RAcP Antibody (2C850) 可用于 ELISA,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μL | ¥ 585 | 5日内发货 | |
| 100 μL | ¥ 1,679 | 5日内发货 |
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抗原信息
| 产品描述 | Anti-IL-1RAP/IL-1RAcP Antibody (2C850) is a Mouse antibody targeting IL-1RAP/IL-1RAcP. Anti-IL-1RAP/IL-1RAcP Antibody (2C850) can be used in ELISA,FCM. |
| 别名 | interleukin 1 receptor accessory protein |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 2C850 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human IL1R3 expression on human whole blood monocytes. Cells were stained with purified anti-Human IL1R3, then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of viable monocytes. |
| 应用 | ELISA,FCM |
| 推荐剂量 | ELISA: 1:1000-1:2000; FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL1R3 / IL1RAP (rh IL1R3; TMPY-01251; NP_002173.1; Met 1-Glu 359). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS with 10% Trehalose, 0.02% Tween 80, pH7.0 |
| 研究背景 | Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. Interleukin 1 induces the synthesis of the acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. IL-1RAcP/IL-1R3 is a necessary part of the interleukin 1 receptor complex which initiates signaling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. IL-1RAcP/IL-1R3 mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves the formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/FITC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human IL1R3 protein (TMPY-01251) |
| 抗原种属 | Human |
| 研究领域 | Neuroinflammation |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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