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Anti-IL-17A Antibody (2W545)
还可以产品编号 TMAY-03537
Anti-IL-17A Antibody (2W545) 是一种 Rabbit 抗体，靶向 IL-17A。Anti-IL-17A Antibody (2W545) 可用于 FCM。
Anti-IL-17A Antibody (2W545)
Anti-IL-17A Antibody (2W545)
还可以产品编号 TMAY-03537
Anti-IL-17A Antibody (2W545) 是一种 Rabbit 抗体，靶向 IL-17A。Anti-IL-17A Antibody (2W545) 可用于 FCM。
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| 产品描述 | Anti-IL-17A Antibody (2W545) is a Rabbit antibody targeting IL-17A. Anti-IL-17A Antibody (2W545) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 2W545 |
| 交叉反应 | Mouse |
| 验证活性 | Flow cytometric analysis of Mouse IL17 expression on EL4 cells.The cells were stimulated for 4-6 hours with PMA and Ionomycin in the presence of GolgiPlug. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Mouse IL17, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL-17A (rM IL-17A; TMPY-02900; Q62386; Thr22-Ala158). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/FITC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Mouse IL-17A Protein (TMPY-02900) |
| 抗原种属 | Mouse |
| 研究领域 | Neuroinflammation |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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