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Anti-IL-10 Antibody-Biotin (1F432)
还可以产品编号 TMAY-01371B
Anti-IL-10 Antibody-Biotin (1F432) 是一种 Biotin-conjugated Mouse 抗体，靶向 IL-10。Anti-IL-10 Antibody-Biotin (1F432) 可用于 ELISA。
Anti-IL-10 Antibody-Biotin (1F432)
Anti-IL-10 Antibody-Biotin (1F432)
还可以产品编号 TMAY-01371B
Anti-IL-10 Antibody-Biotin (1F432) 是一种 Biotin-conjugated Mouse 抗体，靶向 IL-10。Anti-IL-10 Antibody-Biotin (1F432) 可用于 ELISA。
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偶联与修饰
抗原信息
| 产品描述 | Anti-IL-10 Antibody-Biotin (1F432) is a Biotin-conjugated Mouse antibody targeting IL-10. Anti-IL-10 Antibody-Biotin (1F432) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 1F432 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 0.1-1 μg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL10/IL-10/Interleukin-10 (rh IL10/IL-10/Interleukin-10; TMPY-03547; NP_000563.1; Ser 19-Asn 178). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and then biotinylated. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | IL-10 is an anti-inflammatory cytokine that belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells, and other cell types, while it is produced primarily by monocytes and to a lesser extent by lymphocytes. IL-10 is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and also in a certain subset of activated T cells and B cells. IL-10 has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. The importance of interleukin 10 for counteracting excessive immunity in the human body is revealed by the fact that patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant IL-10. IL-10 inhibits the synthesis of some cytokines, including IFN-gamma, IL-2, IL-3, TNF, and GM-CSF produced by activated macrophages and by helper T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen-presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Biotin |
| 其他可选修饰符 | Unconjugated |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Human IL10/IL-10/Interleukin-10 Protein (TMPY-03547) |
| 抗原种属 | Human |
| 研究领域 | Neuroinflammation |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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