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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-GMEB2 Polyclonal Antibody

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货号 TMAB-06598

Anti-GMEB2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GMEB2。Anti-GMEB2 Polyclonal Antibody 可用于 WB。

Anti-GMEB2 Polyclonal Antibody

Anti-GMEB2 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-06598

Anti-GMEB2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GMEB2。Anti-GMEB2 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-GMEB2 Polyclonal Antibody is a Rabbit antibody targeting GMEB2. Anti-GMEB2 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Chicken,Dog,Cow,Horse,Rabbit,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Cytoplasm. May be also cytoplasmic.
组织特异性Expressed in peripheral blood lymphocytes and fetal liver. Expressed preferentially in reproductive and/or developmentally important cells, such as testis, placenta, bone marrow and fetal tissues.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景GMEB-2 is a DNA-binding protein that plays a crucial role modulating transcription upon activation by steroid hormones. GMEB-2 is ubiquitously expressed with preferential expression in developmentally important tissues, such as testis, bone marrow, placenta and fetal tissues. It localizes to the nucleus and cytoplasm and contains a SAND domain near its N-terminus and a C-terminal coiled coil structure. GMEB-2 functions as a homodimer or as a heterodimer with GMEB-1. The formed complex specifically binds to glucocorticoid modulatory elements (GME) in the promoter region of target genes and recruits the histone acetylase CREB binding protein (CBP) during glucocorticoid signaling. This acts to increase sensitivity to low concentrations of glucocorticoids. In addition, GMEB-2 functions as an auxiliary factor required for parvovirus replication.
抗原信息
免疫原
KLH conjugated synthetic peptide: human GMEB2
抗原种属
Human
基因名称
GMEB2
基因ID
26205
蛋白名称
Glucocorticoid modulatory element-binding protein 2
Uniprot ID
Q9UKD1
功能
Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.
化学信息
分子量Theoretical: 56 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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