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Anti-GCN2 Antibody (7U574)

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Anti-GCN2 Antibody (7U574)
产品编号 TMAC-01637
别名 MGCN2, KIAA1338, GCN2-like protein, GCN2 eIF2alpha kinase, GCN2, Eukaryotic Translation Initiation Factor 2-alpha kinase 4, Eukaryotic Translation Initiation Factor 2 alpha kinase 4, Eif2ak4, EIF2AK4, E2AK4

Anti-GCN2 Antibody (7U574) 是一种 Rabbit 抗体，靶向 GCN2。Anti-GCN2 Antibody (7U574) 可用于 WB,ICC,IHC,FCM。

Anti-GCN2 Antibody (7U574)

Anti-GCN2 Antibody (7U574)

Rating icon 还可以
Anti-GCN2 Antibody (7U574)
产品编号 TMAC-01637 别名 MGCN2, KIAA1338, GCN2-like protein, GCN2 eIF2alpha kinase, GCN2, Eukaryotic Translation Initiation Factor 2-alpha kinase 4, Eukaryotic Translation Initiation Factor 2 alpha kinase 4, Eif2ak4, EIF2AK4, E2AK4

Anti-GCN2 Antibody (7U574) 是一种 Rabbit 抗体，靶向 GCN2。Anti-GCN2 Antibody (7U574) 可用于 WB,ICC,IHC,FCM。

规格价格库存数量
50 μL
¥ 1,480
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-GCN2 Antibody (7U574) is a Rabbit antibody targeting GCN2. Anti-GCN2 Antibody (7U574) can be used in WB,ICC,IHC,FCM.
别名MGCN2, KIAA1338, GCN2-like protein, GCN2 eIF2alpha kinase, GCN2, Eukaryotic Translation Initiation Factor 2-alpha kinase 4, Eukaryotic Translation Initiation Factor 2 alpha kinase 4, Eif2ak4, EIF2AK4, E2AK4
Ig Type
IgG
交叉反应
Human
验证活性
1. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-GCN2 antibody. Counter stained with hematoxylin.
2. Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-GCN2 antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-GCN2 antibody. Counter stained with hematoxylin.
4. ICC staining GCN2 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
5. ICC staining GCN2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
6. ICC staining GCN2 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
7. Flow cytometric analysis of MCF-7 cells with GCN2 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).
应用
WB
ICC
IHC
FCM
推荐剂量
WB: 1:500-1000; IHC: 1:50-200; ICC: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The family of stress-responsive protein kinases include HRI (heme-regulated inhibitor or EIF2AK1), PKR (EIF2AK2 or TIK), PERK (EIF2AK3) and GCN2 (EIF2AK4). These proteins phosphorylate the eukaryotic translation initiation factor 2α (eIF2α) on Ser 51 to regulate general and gene-specific protein synthesis. Phosphorylated eIF2α acts as an inhibitor of its guanine nucleotide exchange factor eIF2B. GCN2, a unique eIF2α kinase, exists in all eukaryotes from yeast to mammals. In mammals, expression of GCN2 is highest in liver and brain tissues. GCN2 primarily initiates the phosphorylation of eIF2α in response to UV, but has been shown to increase phosphorylation activity in response to serum starvation. Also, substitution of Asp 83 for Ala on eIF2α results in impaired phosphorylation by GCN2 and PKR, suggesting a contribution of remote residues to kinase-substrate recognition.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
Q9P2K8
化学信息
分子量Theoretical: 187 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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