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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-ERO1LB Polyclonal Antibody

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货号 TMAB-05680

Anti-ERO1LB Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ERO1LB。Anti-ERO1LB Polyclonal Antibody 可用于 WB。

Anti-ERO1LB Polyclonal Antibody

Anti-ERO1LB Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-05680

Anti-ERO1LB Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ERO1LB。Anti-ERO1LB Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-ERO1LB Polyclonal Antibody is a Rabbit antibody targeting ERO1LB. Anti-ERO1LB Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Rabbit,GuineaPig)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Note: The association with ERP44 may be essential for its retention in the endoplasmic reticulum.
组织特异性Highly expressed in the digestive tract, including the duodenum and lower digestive tract. In the stomach, highly expressed in enzyme-producing chief cells (at protein level). In the pancreas, expressed in islets of Langerhans and, at lower levels, in enzyme-secreting cells (at protein level). Detected at low level in many other tissues.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress.
抗原信息
免疫原
KLH conjugated synthetic peptide: human ERO1LB
抗原种属
Human
基因名称
ERO1B
基因ID
56605
蛋白名称
ERO1-like protein beta
Uniprot ID
Q86YB8
功能
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (
化学信息
分子量Theoretical: 50 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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