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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-EFCAB4B Polyclonal Antibody

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货号 TMAB-05456

Anti-EFCAB4B Polyclonal Antibody 是一种 Rabbit 抗体，靶向 EFCAB4B。Anti-EFCAB4B Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-EFCAB4B Polyclonal Antibody

Anti-EFCAB4B Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-05456

Anti-EFCAB4B Polyclonal Antibody 是一种 Rabbit 抗体，靶向 EFCAB4B。Anti-EFCAB4B Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

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产品描述
Anti-EFCAB4B Polyclonal Antibody is a Rabbit antibody targeting EFCAB4B. Anti-EFCAB4B Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Horse,Rabbit,GuineaPig)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景EF-CAB4B is a 395 amino acid protein belonging to the EF-CAB4 family. Localizing to cytoplasm, EF-CAB4B contains two EF-hand domains and exists as two alternatively spliced isoforms. At low Ca2+ concentrations, EF-CAB4B acts as a calcium-sensor, facilitating the clustering of Orai1 and Stim1 at the junctional regions between plasma membrane and endoplasmic reticulum, leading to regulation of CRAC channel activation. The gene encoding EF-CAB4B maps to human chromosome 12p13.32. Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia.
抗原信息
免疫原
KLH conjugated synthetic peptide: human EFCAB4B
抗原种属
Human
基因名称
CRACR2A
基因ID
84766
蛋白名称
EF-hand calcium-binding domain-containing protein 4B
Uniprot ID
Q9BSW2
功能
Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
化学信息
分子量Theoretical: 46/83 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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