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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-DNA Ligase IV Antibody (5M82)

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货号 TMAB-05212

Anti-DNA Ligase IV Antibody (5M82) 是一种 Rabbit 抗体，靶向 DNA Ligase IV。Anti-DNA Ligase IV Antibody (5M82) 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-DNA Ligase IV Antibody (5M82)

Anti-DNA Ligase IV Antibody (5M82)

一键复制产品信息
Rating icon 还可以
货号 TMAB-05212

Anti-DNA Ligase IV Antibody (5M82) 是一种 Rabbit 抗体，靶向 DNA Ligase IV。Anti-DNA Ligase IV Antibody (5M82) 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,380
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-DNA Ligase IV Antibody (5M82) is a Rabbit antibody targeting DNA Ligase IV. Anti-DNA Ligase IV Antibody (5M82) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
克隆号
5M82
反应种属
Human
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-200; IHC-Fr: 1:100-200; IF: 1:100-200
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Testis, thymus, prostate and heart.
组织特异性Testis, thymus, prostate and heart.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The X-ray repair cross-complementing protein XRCC4 and DNA Ligase IV are essential for repairing double-strand breaks in DNA. These proteins form a critical complex consisting of two molecules of each protein that preferentially bind DNA with nicks or broken ends. As an obligate accessory molecule, XRCC4 binds to DNA Ligase IV and enhances its joining activity. The XRCC4/ DNA Ligase IV complex is also involved in V(D)J recombination. V(D)J recombination occurs in normal development of the adaptive immune system and involves the formation of a double-strand break intermediate. Deletions of either DNA Ligase IV or XRCC4 inhibit the completion of V(D)J recombination, resulting in a high incidence of apoptosis in the developing nervous system and a block in B and T cell maturation.
抗原信息
免疫原
Recombinant Protein: human DNA Ligase IV
抗原种属
Human
基因名称
LIG4
基因ID
3981
蛋白名称
DNA ligase 4
Uniprot ID
P49917
功能
Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
化学信息
分子量Theoretical: 104 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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