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Anti-DC-SIGN Antibody-APC (7H439)
还可以产品编号 TMAY-00446A
Anti-DC-SIGN Antibody-APC (7H439) 是一种 APC-conjugated Rabbit 抗体，靶向 DC-SIGN。Anti-DC-SIGN Antibody-APC (7H439) 可用于 FCM。
Anti-DC-SIGN Antibody-APC (7H439)
Anti-DC-SIGN Antibody-APC (7H439)
还可以产品编号 TMAY-00446A
Anti-DC-SIGN Antibody-APC (7H439) 是一种 APC-conjugated Rabbit 抗体，靶向 DC-SIGN。Anti-DC-SIGN Antibody-APC (7H439) 可用于 FCM。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-DC-SIGN Antibody-APC (7H439) is a APC-conjugated Rabbit antibody targeting DC-SIGN. Anti-DC-SIGN Antibody-APC (7H439) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 7H439 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human CD209 expression on DC. Cells were stained with APC-conjugated anti-Human CD209. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human CD209/DC-SIGN (rh CD209/DC-SIGN; TMPY-00772; NP_066978.1; Lys62-Ala404) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin (DC-SIGN), also known as CD209, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has an important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. DC-SIGN also mediates the capture and internalization of viral, bacterial, and fungal pathogens by dendritic cells, such as HIV-1, Ebola virus, cytomegalovirus, Dengue virus, and hepatitis C virus. DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | APC |
| 其他可选修饰符 | Unconjugated/FITC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human CD209/DC-SIGN Protein (TMPY-00772) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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