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Anti-CRTAM Antibody-PE (2G306)
还可以产品编号 TMAY-02175P
Anti-CRTAM Antibody-PE (2G306) 是一种 PE-conjugated Mouse 抗体，靶向 CRTAM。Anti-CRTAM Antibody-PE (2G306) 可用于 FCM。
Anti-CRTAM Antibody-PE (2G306)
Anti-CRTAM Antibody-PE (2G306)
还可以产品编号 TMAY-02175P
Anti-CRTAM Antibody-PE (2G306) 是一种 PE-conjugated Mouse 抗体，靶向 CRTAM。Anti-CRTAM Antibody-PE (2G306) 可用于 FCM。
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产品介绍
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抗原信息
| 产品描述 | Anti-CRTAM Antibody-PE (2G306) is a PE-conjugated Mouse antibody targeting CRTAM. Anti-CRTAM Antibody-PE (2G306) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 2G306 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human CRTAM(CD355) expression on human peripheral blood lymphocytes. Human peripheral blood mononulcear cells were stimulated for 24 hours with PMA and Ionomycin, then stained with PE-conjugated anti-Human CRTAM(CD355) and APC-conjugated anti-Human CD8. The dot plots were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| 应用 | FCM |
| 推荐剂量 | 2 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CRTAM (rh CRTAM; TMPY-01674; NP_062550.2; Met1-Ser286) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | Cytotoxic and regulatory T-cell molecule, also known as Class-I MHC-restricted T-cell-associated molecule and CRTAM, is a single-pass type I membrane protein which belongs to thenectin family.CRTAM contains oneIg-like C2-type (immunoglobulin-like) domain and oneIg-like V-type (immunoglobulin-like) domain. In the immune system, the expression of CRTAM is restricted to activated class-I MHC-restricted cells, including NKT and CD8 cells. It is strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in purkinje neurons in cerebellum. It is expressed at much lower levels in testis, ovary, colon, lung and lymphoid tissues. CRTAM is a member of the immunoglobulin superfamily that complies with the structural characteristics of the JAM family of proteins and is phylogenetically more closely related to nectin-like proteins. It is a molecule involved in epithelial cell adhesion. CRTAM is sensitive to intermediate filament disruption and treatment of monolayers with soluble CRTAM enhances cell-cell dissociation and lowers transepithelial electrical resistance. CRTAM may also induce retention by binding to CD8+ dendritic cells (DCs) at the late stage of activation before proliferation. |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated/APC |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Human CRTAM Protein (TMPY-01674) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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