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Anti-CD31 Antibody (7D666) (ready to use)

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货号 TMAB-03946

Anti-CD31 Antibody (7D666) 是一种 Mouse 抗体，靶向 CD31。Anti-CD31 Antibody (7D666) 可用于 IHC-P,IHC-Fr,ICC/IF,IF。

Anti-CD31 Antibody (7D666) (ready to use)

Anti-CD31 Antibody (7D666) (ready to use)

一键复制产品信息
Rating icon 还可以
货号 TMAB-03946

Anti-CD31 Antibody (7D666) 是一种 Mouse 抗体，靶向 CD31。Anti-CD31 Antibody (7D666) 可用于 IHC-P,IHC-Fr,ICC/IF,IF。

规格价格库存数量
3 mL
¥ 540
5日内发货
6 mL
¥ 965
5日内发货
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
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产品介绍

生物活性
产品描述
Anti-CD31 Antibody (7D666) is a Mouse antibody targeting CD31. Anti-CD31 Antibody (7D666) can be used in IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG1
克隆号
7D666
反应种属
Human
应用IHC-PIHC-FrICC/IFIF
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Isoform Long: Membrane; Single-pass type I membrane protein. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.Isoform Delta15: Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
组织特异性Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells (PubMed:18388311, PubMed:21464369).Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level) (PubMed:19342684, PubMed:17580308).Expressed on neutrophils (at protein level) (PubMed:17580308).Isoform Long predominates in all tissues examined (PubMed:12433657).Isoform Delta12 is detected only in trachea (PubMed:12433657).Isoform Delta14-15 is only detected in lung (PubMed:12433657).Isoform Delta14 is detected in all tissues examined with the strongest expression in heart (PubMed:12433657).Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level) (PubMed:12433657, PubMed:18388311).
构建方式Hybridoma Monoclonal Antibody
纯化方式Protein G purified
性状Liquid
缓冲液0.01M PBS (pH7.4) with 1% BSA and 0.02% Proclin300.
研究背景The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
抗原信息
免疫原
KLH conjugated synthetic peptide: human CD31
抗原种属
Human
基因名称
PECAM1
基因ID
5175
蛋白名称
Platelet endothelial cell adhesion molecule
Uniprot ID
P16284
功能
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308).Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684).Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302).Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308).Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892).Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892).Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896).Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896).Induces susceptibility to atherosclerosis (By similarity).
化学信息
分子量Theoretical: 78 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 12 months, do not freeze.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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