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Anti-Caspase-10 Antibody (3V777)
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产品编号 TMAC-00577
别名 MCH4, ICE-Like Apoptotic Protease 4, FLICE2, FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2, Caspase-10, CASP-10, CASP10, Apoptotic Protease Mch-4
Anti-Caspase-10 Antibody (3V777) 是一种 Rabbit 抗体，靶向 Caspase-10。Anti-Caspase-10 Antibody (3V777) 可用于 WB,IHC,IP,FCM。
Anti-Caspase-10 Antibody (3V777)
Anti-Caspase-10 Antibody (3V777)
还可以产品编号 TMAC-00577 别名 MCH4, ICE-Like Apoptotic Protease 4, FLICE2, FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2, Caspase-10, CASP-10, CASP10, Apoptotic Protease Mch-4
Anti-Caspase-10 Antibody (3V777) 是一种 Rabbit 抗体，靶向 Caspase-10。Anti-Caspase-10 Antibody (3V777) 可用于 WB,IHC,IP,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,495 | 5日内发货 | |
| 100 μL | ¥ 2,495 | 5日内发货 |
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| 产品描述 | Anti-Caspase-10 Antibody (3V777) is a Rabbit antibody targeting Caspase-10. Anti-Caspase-10 Antibody (3V777) can be used in WB,IHC,IP,FCM. |
| 别名 | MCH4, ICE-Like Apoptotic Protease 4, FLICE2, FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2, Caspase-10, CASP-10, CASP10, Apoptotic Protease Mch-4 |
| Ig Type | IgG |
| 交叉反应 | Human |
| 验证活性 | 1. Western blot analysis of Caspase-10 on K562 cells lysates using anti-Caspase-10 antibody at 1/1,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Caspase-10 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Caspase-10 antibody. Counter stained with hematoxylin. 4. Flow cytometric analysis of K562 cells with Caspase-10 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| 应用 | |
| 推荐剂量 | WB: 1:1000-2000; IHC: 1:50-200; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Caspase-10, also designated Mch4, is recruited to the native TRAIL and CD9 death-inducing signaling complexes (DISCs) by the FADD/Mort1 adaptor protein complex. Caspase-10 requires the assembly of the FADD and DISC complexes for its recruitment and cleavage-induced activation during CD95-induced apoptosis of activated T cells. The N-terminus of caspase-10 contains FADD-like death effector domains further indicating that it associates with FADD to induce apoptosis. Caspase-10 is not required for apoptosis induction and when overexpressed, cannot reverse defects in apoptosis induction caused by caspase-8 deficiency. Granzyme B cleaves procaspase-10 at an IXXD-A processing sequence to produce mature caspase-10. Mutations in the caspase-10 gene in the prodomain, p17 large protease subunit and p12 small protease subunit have been linked to a number of non-Hodgkin lymphomas in humans. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 59 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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