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顶部生物活性储存和溶解信息计算器

Anti-Caspase-10 Antibody (3V777)

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产品编号 TMAC-00577

别名 MCH4, ICE-Like Apoptotic Protease 4, FLICE2, FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2, Caspase-10, CASP-10, CASP10, Apoptotic Protease Mch-4

Anti-Caspase-10 Antibody (3V777) 是一种 Rabbit 抗体，靶向 Caspase-10。Anti-Caspase-10 Antibody (3V777) 可用于 FCM,IHC,IP,WB。

Anti-Caspase-10 Antibody (3V777)

Anti-Caspase-10 Antibody (3V777)

一键复制产品信息
Rating icon 还可以
产品编号 TMAC-00577 别名 MCH4, ICE-Like Apoptotic Protease 4, FLICE2, FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2, Caspase-10, CASP-10, CASP10, Apoptotic Protease Mch-4

Anti-Caspase-10 Antibody (3V777) 是一种 Rabbit 抗体，靶向 Caspase-10。Anti-Caspase-10 Antibody (3V777) 可用于 FCM,IHC,IP,WB。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

生物活性
产品描述
Anti-Caspase-10 Antibody (3V777) is a Rabbit antibody targeting Caspase-10. Anti-Caspase-10 Antibody (3V777) can be used in FCM,IHC,IP,WB.
别名MCH4, ICE-Like Apoptotic Protease 4, FLICE2, FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2, Caspase-10, CASP-10, CASP10, Apoptotic Protease Mch-4
Ig Type
IgG
克隆号
3V777
交叉反应
Human
验证活性
1. Western blot analysis of Caspase-10 on K562 cells lysates using anti-Caspase-10 antibody at 1/1,000 dilution.
2. Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Caspase-10 antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Caspase-10 antibody. Counter stained with hematoxylin.
4. Flow cytometric analysis of K562 cells with Caspase-10 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
verifiedActivityverifiedActivityverifiedActivityverifiedActivity
应用FCMIHCIPWB
推荐剂量
WB: 1:1000-2000; IHC: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Caspase-10, also designated Mch4, is recruited to the native TRAIL and CD9 death-inducing signaling complexes (DISCs) by the FADD/Mort1 adaptor protein complex. Caspase-10 requires the assembly of the FADD and DISC complexes for its recruitment and cleavage-induced activation during CD95-induced apoptosis of activated T cells. The N-terminus of caspase-10 contains FADD-like death effector domains further indicating that it associates with FADD to induce apoptosis. Caspase-10 is not required for apoptosis induction and when overexpressed, cannot reverse defects in apoptosis induction caused by caspase-8 deficiency. Granzyme B cleaves procaspase-10 at an IXXD-A processing sequence to produce mature caspase-10. Mutations in the caspase-10 gene in the prodomain, p17 large protease subunit and p12 small protease subunit have been linked to a number of non-Hodgkin lymphomas in humans.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
Q92851
化学信息
分子量Theoretical: 59 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

MCH-4MCH 4FLICE-2FLICE 2CASP 10

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