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Anti-CALML3 Antibody (1W13)
还可以产品编号 TMAY-02365
别名 CLP, calmodulin-like 3
Anti-CALML3 Antibody (1W13) 是一种 Mouse 抗体，靶向 CALML3。Anti-CALML3 Antibody (1W13) 可用于 FCM。
Anti-CALML3 Antibody (1W13)
Anti-CALML3 Antibody (1W13)
还可以产品编号 TMAY-02365 别名 CLP, calmodulin-like 3
Anti-CALML3 Antibody (1W13) 是一种 Mouse 抗体，靶向 CALML3。Anti-CALML3 Antibody (1W13) 可用于 FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,679 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CALML3 Antibody (1W13) is a Mouse antibody targeting CALML3. Anti-CALML3 Antibody (1W13) can be used in FCM. |
| 别名 | CLP, calmodulin-like 3 |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 1W13 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human CALML3 expression on A431 cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human CALML3, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This product is a recombinant monoclonal antibody expressed from HEK293 cells. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Calmodulin-like protein 3 (CALML3) is similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinity, to cellular substrates. Calmodulin-like protein 3 (CALML3) is a tumor-sensitive protein specifically expressed in normal epithelial cells but downregulated in tumorigenesis. Downregulation of the protein is an early event in breast cancer development. One of the most pressing questions raised by the discovery of CLP/CALML3 is that of its potential targets. Although it is 85% identical to human calmodulin, the distinct properties of CLP suggest that it has specific targets or targets that only partially overlap with those of calmodulin. Research has identified the unconventional myosin-10 (Myo10) as a specific target of CALML3. The discovery of Myo10 as a specific target of CALML3 is highly significant and suggests multiple lines of further research such as investigations of the Ca2+ regulation of Myo10 and the role of the loss of CLP in epithelial differentiation, adhesion, and cancer. Cells expressing CALML3 displayed a striking increase in the number and length of myosin-10-positive filopodia and showed increased mobility in a wound healing assay. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human CALML3 Protein (TMPY-02760) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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