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顶部生物活性储存和溶解信息计算器

Anti-BID Antibody-FITC (9U548)

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Anti-BID Antibody-FITC (9U548)
产品编号 TMAY-00869F
别名 BH3 interacting domain death agonist, AU022477, AI875481, 2700049M22Rik

Anti-BID Antibody-FITC (9U548) 是一种 FITC-conjugated Mouse 抗体，靶向 BID。Anti-BID Antibody-FITC (9U548) 可用于 FCM。

Anti-BID Antibody-FITC (9U548)

Anti-BID Antibody-FITC (9U548)

Rating icon 还可以
Anti-BID Antibody-FITC (9U548)
产品编号 TMAY-00869F 别名 BH3 interacting domain death agonist, AU022477, AI875481, 2700049M22Rik

Anti-BID Antibody-FITC (9U548) 是一种 FITC-conjugated Mouse 抗体，靶向 BID。Anti-BID Antibody-FITC (9U548) 可用于 FCM。

规格价格库存数量
25 T
¥ 890
5日内发货
100 T
¥ 1,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-BID Antibody-FITC (9U548) is a FITC-conjugated Mouse antibody targeting BID. Anti-BID Antibody-FITC (9U548) can be used in FCM.
别名BH3 interacting domain death agonist, AU022477, AI875481, 2700049M22Rik
Ig Type
Mouse IgG1
克隆号
9U548
交叉反应
Human
验证活性
Flow cytometric analysis of BID expression on Jurkat cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with FITC Mouse anti-BID. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
应用
FCM
推荐剂量
10 μl/Test, 0.1 mg/ml
抗体种类
Monoclonal
宿主来源Mouse
构建方式This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human BID (rh BID; TMPY-02027; P55957-1; Met 1-Asp 195) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
纯化方式Protein A
性状Liquid
缓冲液PBS solution containing 0.5% BSA and 0.09% sodium azide
研究背景The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. BID is important to cell death mediated by these proteases and thus is the sentinel to protease-mediated death signals. Recent studies further indicate that Bid may be more than just a killer molecule, it could be also involved in the maintenance of genomic stability by engaging at mitosis checkpoint. BID is an integrating key regulator of the intrinsic death pathway that amplifies caspase-dependent and caspase-independent execution of neuronal apoptosis. Therefore pharmacological inhibition of BID provides a promising therapeutic strategy in neurological diseases where programmed cell death is prominent. BID is activated by Caspase 8 in response to Fas/TNF-R1 death receptor activation. Activated BID is translocated to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. BID action has been proposed to involve the mitochondrial re-location of its truncated form, tBid, to facilitate the release of apoptogenic proteins like cytochrome c.
偶联与修饰
偶联
FITC
其他可选修饰符
Unconjugated
可提供抗体种类
2
抗原信息
免疫原
Recombinant Protein: Human BID protein (TMPY-02027)
抗原种属
Human
存储&运输
储存方式Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
运输方式Shipping with blue ice.

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关键词

AU-022477AU 022477AI-875481AI 875481

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