Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Z944 是有效的 T 型钙通道拮抗剂,对跨模态和视觉识别记忆障碍有缓解作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 438 | 现货 | ||
2 mg | ¥ 639 | 现货 | ||
5 mg | ¥ 1,060 | 现货 | ||
10 mg | ¥ 1,580 | 现货 | ||
25 mg | ¥ 2,670 | 现货 | ||
50 mg | ¥ 3,920 | 现货 | ||
100 mg | ¥ 5,580 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,090 | 现货 |
产品描述 | Z944 is a T-type calcium channel blocker. Z944 delays the progression of seizures in the amygdala kindling model. Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats. |
体内活性 | Z944 dose dependently (1, 3, 10mg/kg; i.p.) altered CMOR memory in GAERS compared to the non-epileptic control (NEC) strain. GAERS demonstrated recognition memory deficits in the visual and crossmodal variations of the CMOR task that were reversed by the highest dose of Z944. Electroencephalogram recordings determined that deficits in CMOR memory in GAERS were not the result of seizures during task performance. In contrast, NEC showed a decrease in CMOR memory following Z944 treatment[2]. |
别名 | Z 944, Z-944 |
分子量 | 383.89 |
分子式 | C19H27ClFN3O2 |
CAS No. | 1199236-64-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 13 mg/ml (33.86 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6049 mL | 13.0246 mL | 26.0491 mL | 65.1228 mL |
5 mM | 0.521 mL | 2.6049 mL | 5.2098 mL | 13.0246 mL | |
10 mM | 0.2605 mL | 1.3025 mL | 2.6049 mL | 6.5123 mL | |
20 mM | 0.1302 mL | 0.6512 mL | 1.3025 mL | 3.2561 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Z944 1199236-64-0 Membrane transporter/Ion channel Metabolism Calcium Channel Ca channels Inhibitor Z 944 Ca2+ channels Z-944 inhibit inhibitor