Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Succinobucol (Probucol monosuccinate) 是酚类抗氧化剂,具有抗炎、抗血小板聚集活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 297 | 现货 | ||
5 mg | ¥ 493 | 现货 | ||
10 mg | ¥ 828 | 现货 | ||
25 mg | ¥ 1,660 | 现货 | ||
50 mg | ¥ 2,820 | 现货 | ||
100 mg | ¥ 4,250 | 现货 | ||
500 mg | ¥ 9,180 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 675 | 现货 |
产品描述 | Succinobucol (Probucol monosuccinate) is a novel phenolic antioxidant small molecule with anti-oxidant and anti-inflammatory properties. It designed to treat atherosclerosis of the blood vessels of the heart or coronary artery disease. |
体外活性 | In rabbit whole blood, Succinobucol (10, 50, 100 μM) causes a dose-dependent reduction in collagen-induced platelet aggregation. Succinobucol (10, 100 μM) significantly lowers the relaxation to X/XO. |
体内活性 | In lung metastatic breast cancer mice, Succinobucol (40 mg/kg) by tail injection significantly reduces the average number of metastatic nodules. In rats, Succinobucol (50, 100, and 150 mg/kg, i.v.) has no significant effect on either heart rate or MAP. |
细胞实验 | In the metastatic 4T1 breast cancer cells, Succinobucol, SCB and the PCD polymer (equivalent concentration to SCB) are respectively added to each well with SCB concentrations ranging from 4 ng/mL to 40 μg/mL. |
动物实验 | Mice, injected 4T1-luc cells, are treated with Succinobucol (40 mg/kg) by tail injection every three days. |
别名 | Probucol monosuccinate, AGI-1067 |
分子量 | 616.91 |
分子式 | C35H52O5S2 |
CAS No. | 216167-82-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 162.1 mM
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.621 mL | 8.1049 mL | 16.2098 mL | 40.5245 mL |
5 mM | 0.3242 mL | 1.621 mL | 3.242 mL | 8.1049 mL | |
10 mM | 0.1621 mL | 0.8105 mL | 1.621 mL | 4.0525 mL | |
20 mM | 0.081 mL | 0.4052 mL | 0.8105 mL | 2.0262 mL | |
50 mM | 0.0324 mL | 0.1621 mL | 0.3242 mL | 0.8105 mL | |
100 mM | 0.0162 mL | 0.081 mL | 0.1621 mL | 0.4052 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Succinobucol 216167-82-7 Immunology/Inflammation Metabolism NF-Κb oxidation-reduction Antioxidant Reactive Oxygen Species Inhibitor inhibit Probucol monosuccinate Probucol Monosuccinate AGI1067 AGI-1067 Probucol AGI 1067 inhibitor